The bla(NDM-1)-Carrying IncA/C(2) Plasmid Underlies Structural Alterations and Cointegrate Formation In Vivo

In 2012, a carbapenemase-producing Salmonella enterica serovar Corvallis isolate carrying a bla(NDM-1) multiresistance IncA/C(2) plasmid, apart from IncHI2 and ColE-like plasmids, was detected in a wild bird in Germany. In a recent broiler chicken infection study, we observed transfer of this bla(ND...

Descripción completa

Detalles Bibliográficos
Autores principales: Hadziabdic, Sead, Fischer, Jennie, Borowiak, Maria, Malorny, Burkhard, Juraschek, Katharina, Kaesbohrer, Annemarie, Guerra, Beatriz, Deneke, Carlus, Gonzalez-Zorn, Bruno, Szabo, Istvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658791/
https://www.ncbi.nlm.nih.gov/pubmed/31109975
http://dx.doi.org/10.1128/AAC.00380-19
Descripción
Sumario:In 2012, a carbapenemase-producing Salmonella enterica serovar Corvallis isolate carrying a bla(NDM-1) multiresistance IncA/C(2) plasmid, apart from IncHI2 and ColE-like plasmids, was detected in a wild bird in Germany. In a recent broiler chicken infection study, we observed transfer of this bla(NDM-1)-carrying IncA/C(2) plasmid to other Enterobacteriaceae. Here, we focused on the stability of this plasmid and gained insight into the type and frequency of its structural alterations after an in vivo passage in a broiler chicken infection study.

Ejemplares similares