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Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition
Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is essential for tissue patterning and organization, and it has also been implicated in a wide array of pathologies. Wh...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658819/ https://www.ncbi.nlm.nih.gov/pubmed/31380370 http://dx.doi.org/10.3389/fcell.2019.00135 |
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author | Scott, Lewis E. Weinberg, Seth H. Lemmon, Christopher A. |
author_facet | Scott, Lewis E. Weinberg, Seth H. Lemmon, Christopher A. |
author_sort | Scott, Lewis E. |
collection | PubMed |
description | Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is essential for tissue patterning and organization, and it has also been implicated in a wide array of pathologies. While the intracellular signaling pathways that regulate EMT are well-understood, there is increasing evidence that the mechanical properties and composition of the extracellular matrix (ECM) also play a key role in regulating EMT. In turn, EMT drives changes in the mechanics and composition of the ECM, creating a feedback loop that is tightly regulated in healthy tissues, but is often dysregulated in disease. Here we present a review that summarizes our understanding of how ECM mechanics and composition regulate EMT, and how in turn EMT alters ECM mechanics and composition. |
format | Online Article Text |
id | pubmed-6658819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66588192019-08-02 Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition Scott, Lewis E. Weinberg, Seth H. Lemmon, Christopher A. Front Cell Dev Biol Cell and Developmental Biology Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is essential for tissue patterning and organization, and it has also been implicated in a wide array of pathologies. While the intracellular signaling pathways that regulate EMT are well-understood, there is increasing evidence that the mechanical properties and composition of the extracellular matrix (ECM) also play a key role in regulating EMT. In turn, EMT drives changes in the mechanics and composition of the ECM, creating a feedback loop that is tightly regulated in healthy tissues, but is often dysregulated in disease. Here we present a review that summarizes our understanding of how ECM mechanics and composition regulate EMT, and how in turn EMT alters ECM mechanics and composition. Frontiers Media S.A. 2019-07-19 /pmc/articles/PMC6658819/ /pubmed/31380370 http://dx.doi.org/10.3389/fcell.2019.00135 Text en Copyright © 2019 Scott, Weinberg and Lemmon. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Scott, Lewis E. Weinberg, Seth H. Lemmon, Christopher A. Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition |
title | Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition |
title_full | Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition |
title_fullStr | Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition |
title_full_unstemmed | Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition |
title_short | Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition |
title_sort | mechanochemical signaling of the extracellular matrix in epithelial-mesenchymal transition |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658819/ https://www.ncbi.nlm.nih.gov/pubmed/31380370 http://dx.doi.org/10.3389/fcell.2019.00135 |
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