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Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson’s disease
Ever since its introduction 40 years ago l-3,4-dihydroxyphenylalanine (l-DOPA) therapy has retained its role as the leading standard medication for patients with Parkinson’s disease. With time, however, the shortcomings of oral l-DOPA treatment have become apparent, particularly the motor fluctuatio...
Autores principales: | Rosenblad, Carl, Li, Qin, Pioli, Elsa Y., Dovero, Sandra, Antunes, André SLM, Agúndez, Leticia, Bardelli, Martino, Linden, R. Michael, Henckaerts, Els, Björklund, Anders, Bezard, Erwan, Björklund, Tomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658866/ https://www.ncbi.nlm.nih.gov/pubmed/31243443 http://dx.doi.org/10.1093/brain/awz176 |
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