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The crystal structure of (RS)-7-chloro-2-(2,5-di­meth­oxy­phen­yl)-2,3-di­hydro­quinazolin-4(1H)-one: two hydrogen bonds generate an elegant three-dimensional framework structure

In the title compound, C(61)H(15)ClN(2)O(3), the heterocyclic ring adopts an envelope conformation, folded across the N⋯N line, with the 2,5-di­meth­oxy­phenyl unit occupying a quasi-axial site. There are two N—H⋯O hydrogen bonds in the structure: one hydrogen bond links mol­ecules related by a 4(1)...

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Detalles Bibliográficos
Autores principales: Narasimhamurthy, Kereyagalahally H., Chandra, Sagar, Belakavadi K., Rangappa, Kanchugarakoppal S., Yathirajan, Hemmige S., Glidewell, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658962/
https://www.ncbi.nlm.nih.gov/pubmed/31391979
http://dx.doi.org/10.1107/S2056989019007023
Descripción
Sumario:In the title compound, C(61)H(15)ClN(2)O(3), the heterocyclic ring adopts an envelope conformation, folded across the N⋯N line, with the 2,5-di­meth­oxy­phenyl unit occupying a quasi-axial site. There are two N—H⋯O hydrogen bonds in the structure: one hydrogen bond links mol­ecules related by a 4(1) screw axis to form a C(6) chain, and the other links inversion-related pairs of mol­ecules to form an R (2) (2)(8) ring. The ring motif links all of the chains into a continuous three-dimensional framework structure. Comparisons are made with the structures of some related compounds.