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The crystal structure of (RS)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one: two hydrogen bonds generate an elegant three-dimensional framework structure
In the title compound, C(61)H(15)ClN(2)O(3), the heterocyclic ring adopts an envelope conformation, folded across the N⋯N line, with the 2,5-dimethoxyphenyl unit occupying a quasi-axial site. There are two N—H⋯O hydrogen bonds in the structure: one hydrogen bond links molecules related by a 4(1)...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658962/ https://www.ncbi.nlm.nih.gov/pubmed/31391979 http://dx.doi.org/10.1107/S2056989019007023 |
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| author | Narasimhamurthy, Kereyagalahally H. Chandra, Sagar, Belakavadi K. Rangappa, Kanchugarakoppal S. Yathirajan, Hemmige S. Glidewell, Christopher |
| author_facet | Narasimhamurthy, Kereyagalahally H. Chandra, Sagar, Belakavadi K. Rangappa, Kanchugarakoppal S. Yathirajan, Hemmige S. Glidewell, Christopher |
| author_sort | Narasimhamurthy, Kereyagalahally H. |
| collection | PubMed |
| description | In the title compound, C(61)H(15)ClN(2)O(3), the heterocyclic ring adopts an envelope conformation, folded across the N⋯N line, with the 2,5-dimethoxyphenyl unit occupying a quasi-axial site. There are two N—H⋯O hydrogen bonds in the structure: one hydrogen bond links molecules related by a 4(1) screw axis to form a C(6) chain, and the other links inversion-related pairs of molecules to form an R (2) (2)(8) ring. The ring motif links all of the chains into a continuous three-dimensional framework structure. Comparisons are made with the structures of some related compounds. |
| format | Online Article Text |
| id | pubmed-6658962 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-66589622019-08-07 The crystal structure of (RS)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one: two hydrogen bonds generate an elegant three-dimensional framework structure Narasimhamurthy, Kereyagalahally H. Chandra, Sagar, Belakavadi K. Rangappa, Kanchugarakoppal S. Yathirajan, Hemmige S. Glidewell, Christopher Acta Crystallogr E Crystallogr Commun Research Communications In the title compound, C(61)H(15)ClN(2)O(3), the heterocyclic ring adopts an envelope conformation, folded across the N⋯N line, with the 2,5-dimethoxyphenyl unit occupying a quasi-axial site. There are two N—H⋯O hydrogen bonds in the structure: one hydrogen bond links molecules related by a 4(1) screw axis to form a C(6) chain, and the other links inversion-related pairs of molecules to form an R (2) (2)(8) ring. The ring motif links all of the chains into a continuous three-dimensional framework structure. Comparisons are made with the structures of some related compounds. International Union of Crystallography 2019-05-21 /pmc/articles/PMC6658962/ /pubmed/31391979 http://dx.doi.org/10.1107/S2056989019007023 Text en © Narasimhamurthy et al. 2019 http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Research Communications Narasimhamurthy, Kereyagalahally H. Chandra, Sagar, Belakavadi K. Rangappa, Kanchugarakoppal S. Yathirajan, Hemmige S. Glidewell, Christopher The crystal structure of (RS)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one: two hydrogen bonds generate an elegant three-dimensional framework structure |
| title | The crystal structure of (RS)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one: two hydrogen bonds generate an elegant three-dimensional framework structure |
| title_full | The crystal structure of (RS)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one: two hydrogen bonds generate an elegant three-dimensional framework structure |
| title_fullStr | The crystal structure of (RS)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one: two hydrogen bonds generate an elegant three-dimensional framework structure |
| title_full_unstemmed | The crystal structure of (RS)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one: two hydrogen bonds generate an elegant three-dimensional framework structure |
| title_short | The crystal structure of (RS)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one: two hydrogen bonds generate an elegant three-dimensional framework structure |
| title_sort | crystal structure of (rs)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1h)-one: two hydrogen bonds generate an elegant three-dimensional framework structure |
| topic | Research Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658962/ https://www.ncbi.nlm.nih.gov/pubmed/31391979 http://dx.doi.org/10.1107/S2056989019007023 |
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