Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod

Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor and is widely used for relapsing-remitting multiple sclerosis (MS). Here we report the first case of non-traumatic acute epidural hematoma in a relapsing-remitting MS patient treated with fingolimod. Fingolimod might...

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Detalles Bibliográficos
Autores principales: Fukai, Ryoko, Takahashi, Keita, Abe, Hiroyuki, Higashiyama, Yuichi, Doi, Hiroshi, Takeuchi, Hideyuki, Tanaka, Fumiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659100/
https://www.ncbi.nlm.nih.gov/pubmed/31379717
http://dx.doi.org/10.3389/fneur.2019.00763
Descripción
Sumario:Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor and is widely used for relapsing-remitting multiple sclerosis (MS). Here we report the first case of non-traumatic acute epidural hematoma in a relapsing-remitting MS patient treated with fingolimod. Fingolimod might increase the risk of hemorrhage by enhancing vasospasm and causing vascular disruption. Switching fingolimod to other disease-modifying drugs, including dimethyl fumarate, should be considered when non-traumatic hemorrhage is observed in MS patients.

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