Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod

Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor and is widely used for relapsing-remitting multiple sclerosis (MS). Here we report the first case of non-traumatic acute epidural hematoma in a relapsing-remitting MS patient treated with fingolimod. Fingolimod might...

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Autores principales: Fukai, Ryoko, Takahashi, Keita, Abe, Hiroyuki, Higashiyama, Yuichi, Doi, Hiroshi, Takeuchi, Hideyuki, Tanaka, Fumiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659100/
https://www.ncbi.nlm.nih.gov/pubmed/31379717
http://dx.doi.org/10.3389/fneur.2019.00763
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author Fukai, Ryoko
Takahashi, Keita
Abe, Hiroyuki
Higashiyama, Yuichi
Doi, Hiroshi
Takeuchi, Hideyuki
Tanaka, Fumiaki
author_facet Fukai, Ryoko
Takahashi, Keita
Abe, Hiroyuki
Higashiyama, Yuichi
Doi, Hiroshi
Takeuchi, Hideyuki
Tanaka, Fumiaki
author_sort Fukai, Ryoko
collection PubMed
description Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor and is widely used for relapsing-remitting multiple sclerosis (MS). Here we report the first case of non-traumatic acute epidural hematoma in a relapsing-remitting MS patient treated with fingolimod. Fingolimod might increase the risk of hemorrhage by enhancing vasospasm and causing vascular disruption. Switching fingolimod to other disease-modifying drugs, including dimethyl fumarate, should be considered when non-traumatic hemorrhage is observed in MS patients.
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spelling pubmed-66591002019-08-02 Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod Fukai, Ryoko Takahashi, Keita Abe, Hiroyuki Higashiyama, Yuichi Doi, Hiroshi Takeuchi, Hideyuki Tanaka, Fumiaki Front Neurol Neurology Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor and is widely used for relapsing-remitting multiple sclerosis (MS). Here we report the first case of non-traumatic acute epidural hematoma in a relapsing-remitting MS patient treated with fingolimod. Fingolimod might increase the risk of hemorrhage by enhancing vasospasm and causing vascular disruption. Switching fingolimod to other disease-modifying drugs, including dimethyl fumarate, should be considered when non-traumatic hemorrhage is observed in MS patients. Frontiers Media S.A. 2019-07-19 /pmc/articles/PMC6659100/ /pubmed/31379717 http://dx.doi.org/10.3389/fneur.2019.00763 Text en Copyright © 2019 Fukai, Takahashi, Abe, Higashiyama, Doi, Takeuchi and Tanaka. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Fukai, Ryoko
Takahashi, Keita
Abe, Hiroyuki
Higashiyama, Yuichi
Doi, Hiroshi
Takeuchi, Hideyuki
Tanaka, Fumiaki
Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod
title Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod
title_full Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod
title_fullStr Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod
title_full_unstemmed Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod
title_short Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod
title_sort non-traumatic acute epidural hematoma in multiple sclerosis treated with fingolimod
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659100/
https://www.ncbi.nlm.nih.gov/pubmed/31379717
http://dx.doi.org/10.3389/fneur.2019.00763
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