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Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain

Neuropathic pain conditions severely and chronically affect the quality of life in a large human population, but the pain conditions are not adequately managed due to poor understanding of their underlying mechanisms. There is a pressing need for further research into this field to help develop effe...

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Detalles Bibliográficos
Autores principales: Abd-Elsayed, Alaa, Jackson, Markus, Gu, Steven L, Fiala, Kenneth, Gu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659175/
https://www.ncbi.nlm.nih.gov/pubmed/31342847
http://dx.doi.org/10.1177/1744806919864256
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author Abd-Elsayed, Alaa
Jackson, Markus
Gu, Steven L
Fiala, Kenneth
Gu, Jianguo
author_facet Abd-Elsayed, Alaa
Jackson, Markus
Gu, Steven L
Fiala, Kenneth
Gu, Jianguo
author_sort Abd-Elsayed, Alaa
collection PubMed
description Neuropathic pain conditions severely and chronically affect the quality of life in a large human population, but the pain conditions are not adequately managed due to poor understanding of their underlying mechanisms. There is a pressing need for further research into this field to help develop effective and nonaddictive medications to treat neuropathic pain. This article first describes general clinical classification of pain, types and symptoms of neuropathic pain, and current practices of clinical management for neuropathic pain. This is followed by a discussion of various cellular and molecular mechanisms responsible for the development and maintenance of neuropathic pain. In this review, we highlight the loss of function of Kv7 voltage-gated potassium as a mechanism of neuropathic pain and the potential use of Kv7 channel activator as subsequent treatment.
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spelling pubmed-66591752019-08-05 Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain Abd-Elsayed, Alaa Jackson, Markus Gu, Steven L Fiala, Kenneth Gu, Jianguo Mol Pain Review Neuropathic pain conditions severely and chronically affect the quality of life in a large human population, but the pain conditions are not adequately managed due to poor understanding of their underlying mechanisms. There is a pressing need for further research into this field to help develop effective and nonaddictive medications to treat neuropathic pain. This article first describes general clinical classification of pain, types and symptoms of neuropathic pain, and current practices of clinical management for neuropathic pain. This is followed by a discussion of various cellular and molecular mechanisms responsible for the development and maintenance of neuropathic pain. In this review, we highlight the loss of function of Kv7 voltage-gated potassium as a mechanism of neuropathic pain and the potential use of Kv7 channel activator as subsequent treatment. SAGE Publications 2019-07-25 /pmc/articles/PMC6659175/ /pubmed/31342847 http://dx.doi.org/10.1177/1744806919864256 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Abd-Elsayed, Alaa
Jackson, Markus
Gu, Steven L
Fiala, Kenneth
Gu, Jianguo
Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain
title Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain
title_full Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain
title_fullStr Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain
title_full_unstemmed Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain
title_short Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain
title_sort neuropathic pain and kv7 voltage-gated potassium channels: the potential role of kv7 activators in the treatment of neuropathic pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659175/
https://www.ncbi.nlm.nih.gov/pubmed/31342847
http://dx.doi.org/10.1177/1744806919864256
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