Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma

BACKGROUND: CDK9 inhibitors are antitumorigenic against solid tumors, including esophageal adenocarcinoma (EAC). However, efficacy of a CDK9 inhibitor combined with 5-fluorouracil (5-FU) and target proteins that are targeted by these agents in EAC are unknown. METHODS: The anti-EAC efficacy of a new...

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Detalles Bibliográficos
Autores principales: Tong, Zhimin, Mejia, Alicia, Veeranki, Omkara, Verma, Anuj, Correa, Arlene M., Dokey, Rashmi, Patel, Viren, Solis, Luisa Maren, Mino, Barbara, Kathkuda, Riham, Rodriguez-Canales, Jaime, Lin, Steven H., Krishnan, Sunil, Kopetz, Scott, Blum, Mariela, Ajani, Jaffer A., Hofstetter, Wayne L., Maru, Dipen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659187/
https://www.ncbi.nlm.nih.gov/pubmed/31384313
http://dx.doi.org/10.1177/1758835919864850

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