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Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption

BACKGROUND: Two-sample summary-data Mendelian randomization (MR) incorporating multiple genetic variants within a meta-analysis framework is a popular technique for assessing causality in epidemiology. If all genetic variants satisfy the instrumental variable (IV) and necessary modelling assumptions...

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Detalles Bibliográficos
Autores principales:	Bowden, Jack, Del Greco M, Fabiola, Minelli, Cosetta, Zhao, Qingyuan, Lawlor, Debbie A, Sheehan, Nuala A, Thompson, John, Davey Smith, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Mendelian Randomization
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659376/ https://www.ncbi.nlm.nih.gov/pubmed/30561657 http://dx.doi.org/10.1093/ije/dyy258

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