European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects

Background: Cisplatin, a powerful antitumor agent, causes formation of DNA adducts, and activation of apoptotic pathways. Presently, cisplatin resistance develops in up to 70% of patients but the underlying molecular mechanism(s) are unclear and there are no markers to determine which patients will...

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Detalles Bibliográficos
Autores principales: Patel, Tej H., Norman, Lucas, Chang, Steven, Abedi, Sina, Liu, Catherine, Chwa, Marilyn, Atilano, Shari R., Thaker, Kunal, Lu, Stephanie, Jazwinski, S. Michal, Miceli, Michael V., Udar, Nitin, Bota, Daniela, Kenney, M. Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659439/
https://www.ncbi.nlm.nih.gov/pubmed/31380278
http://dx.doi.org/10.3389/fonc.2019.00640

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