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Regulation of Eicosanoid Pathways by MicroRNAs
Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammato...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659501/ https://www.ncbi.nlm.nih.gov/pubmed/31379585 http://dx.doi.org/10.3389/fphar.2019.00824 |
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author | Saul, Meike J. Emmerich, Anne C. Steinhilber, Dieter Suess, Beatrix |
author_facet | Saul, Meike J. Emmerich, Anne C. Steinhilber, Dieter Suess, Beatrix |
author_sort | Saul, Meike J. |
collection | PubMed |
description | Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis. |
format | Online Article Text |
id | pubmed-6659501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66595012019-08-02 Regulation of Eicosanoid Pathways by MicroRNAs Saul, Meike J. Emmerich, Anne C. Steinhilber, Dieter Suess, Beatrix Front Pharmacol Pharmacology Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis. Frontiers Media S.A. 2019-07-19 /pmc/articles/PMC6659501/ /pubmed/31379585 http://dx.doi.org/10.3389/fphar.2019.00824 Text en Copyright © 2019 Saul, Emmerich, Steinhilber and Suess http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Saul, Meike J. Emmerich, Anne C. Steinhilber, Dieter Suess, Beatrix Regulation of Eicosanoid Pathways by MicroRNAs |
title | Regulation of Eicosanoid Pathways by MicroRNAs |
title_full | Regulation of Eicosanoid Pathways by MicroRNAs |
title_fullStr | Regulation of Eicosanoid Pathways by MicroRNAs |
title_full_unstemmed | Regulation of Eicosanoid Pathways by MicroRNAs |
title_short | Regulation of Eicosanoid Pathways by MicroRNAs |
title_sort | regulation of eicosanoid pathways by micrornas |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659501/ https://www.ncbi.nlm.nih.gov/pubmed/31379585 http://dx.doi.org/10.3389/fphar.2019.00824 |
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