Stochastic modeling of phenotypic switching and chemoresistance in cancer cell populations

Phenotypic heterogeneity in cancer cells is widely observed and is often linked to drug resistance. In several cases, such heterogeneity in drug sensitivity of tumors is driven by stochastic and reversible acquisition of a drug tolerant phenotype by individual cells even in an isogenic population. A...

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Detalles Bibliográficos
Autores principales: Kumar, Niraj, Cramer, Gwendolyn M., Dahaj, Seyed Alireza Zamani, Sundaram, Bala, Celli, Jonathan P., Kulkarni, Rahul V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659620/
https://www.ncbi.nlm.nih.gov/pubmed/31350465
http://dx.doi.org/10.1038/s41598-019-46926-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659620/
https://www.ncbi.nlm.nih.gov/pubmed/31350465
http://dx.doi.org/10.1038/s41598-019-46926-x

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