Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN

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Four terbium radioisotopes ((149, 152, 155, 161)Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MED...

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Autores principales: Webster, Ben, Ivanov, Peter, Russell, Ben, Collins, Sean, Stora, Thierry, Ramos, Joao Pedro, Köster, Ulli, Robinson, Andrew Paul, Read, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659625/
https://www.ncbi.nlm.nih.gov/pubmed/31350422
http://dx.doi.org/10.1038/s41598-019-47463-3
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author Webster, Ben
Ivanov, Peter
Russell, Ben
Collins, Sean
Stora, Thierry
Ramos, Joao Pedro
Köster, Ulli
Robinson, Andrew Paul
Read, David
author_facet Webster, Ben
Ivanov, Peter
Russell, Ben
Collins, Sean
Stora, Thierry
Ramos, Joao Pedro
Köster, Ulli
Robinson, Andrew Paul
Read, David
author_sort Webster, Ben
collection PubMed
description Four terbium radioisotopes ((149, 152, 155, 161)Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MEDICIS facilities contains radioactive (139)Ce(16)O and also zinc or gold, depending on the catcher foil used. A method using ion-exchange and extraction chromatography resins in two column separation steps has been developed to isolate (155)Tb with a chemical yield of ≥95% and radionuclidic purity ≥99.9%. Conversion of terbium into a form suitable for chelation to targeting molecules in diagnostic nuclear medicine is presented. The resulting (155)Tb preparations are suitable for the determination of absolute activity, SPECT phantom imaging studies and pre-clinical trials.
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spelling pubmed-66596252019-08-01 Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN Webster, Ben Ivanov, Peter Russell, Ben Collins, Sean Stora, Thierry Ramos, Joao Pedro Köster, Ulli Robinson, Andrew Paul Read, David Sci Rep Article Four terbium radioisotopes ((149, 152, 155, 161)Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MEDICIS facilities contains radioactive (139)Ce(16)O and also zinc or gold, depending on the catcher foil used. A method using ion-exchange and extraction chromatography resins in two column separation steps has been developed to isolate (155)Tb with a chemical yield of ≥95% and radionuclidic purity ≥99.9%. Conversion of terbium into a form suitable for chelation to targeting molecules in diagnostic nuclear medicine is presented. The resulting (155)Tb preparations are suitable for the determination of absolute activity, SPECT phantom imaging studies and pre-clinical trials. Nature Publishing Group UK 2019-07-26 /pmc/articles/PMC6659625/ /pubmed/31350422 http://dx.doi.org/10.1038/s41598-019-47463-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Webster, Ben
Ivanov, Peter
Russell, Ben
Collins, Sean
Stora, Thierry
Ramos, Joao Pedro
Köster, Ulli
Robinson, Andrew Paul
Read, David
Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN
title Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN
title_full Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN
title_fullStr Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN
title_full_unstemmed Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN
title_short Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN
title_sort chemical purification of terbium-155 from pseudo-isobaric impurities in a mass separated source produced at cern
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659625/
https://www.ncbi.nlm.nih.gov/pubmed/31350422
http://dx.doi.org/10.1038/s41598-019-47463-3
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