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Preferential phosphatidylinositol 5-phosphate binding contributes to a destabilization of the VHS domain structure of Tom1

Tom1 transports endosomal ubiquitinated proteins that are targeted for degradation in the lysosomal pathway. Infection of eukaryotic cells by Shigella flexneri boosts oxygen consumption and promotes the synthesis of phosphatidylinositol-5-phosphate (PtdIns5P), which triggers Tom1 translocation to si...

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Detalles Bibliográficos
Autores principales:	Xiong, Wen, Tang, Tuo-Xian, Littleton, Evan, Karcini, Arba, Lazar, Iulia M., Capelluto, Daniel G. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659632/ https://www.ncbi.nlm.nih.gov/pubmed/31350523 http://dx.doi.org/10.1038/s41598-019-47386-z

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