Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans

Several vaccines are approved in the United States for seasonal influenza vaccination every year. Here we compare the impact of repeat influenza vaccination on hemagglutination inhibition (HI) titers, antibody binding and affinity maturation to individual hemagglutinin (HA) domains, HA1 and HA2, acr...

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Autores principales: Khurana, Surender, Hahn, Megan, Coyle, Elizabeth M., King, Lisa R., Lin, Tsai-Lien, Treanor, John, Sant, Andrea, Golding, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659679/
https://www.ncbi.nlm.nih.gov/pubmed/31350391
http://dx.doi.org/10.1038/s41467-019-11296-5
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author Khurana, Surender
Hahn, Megan
Coyle, Elizabeth M.
King, Lisa R.
Lin, Tsai-Lien
Treanor, John
Sant, Andrea
Golding, Hana
author_facet Khurana, Surender
Hahn, Megan
Coyle, Elizabeth M.
King, Lisa R.
Lin, Tsai-Lien
Treanor, John
Sant, Andrea
Golding, Hana
author_sort Khurana, Surender
collection PubMed
description Several vaccines are approved in the United States for seasonal influenza vaccination every year. Here we compare the impact of repeat influenza vaccination on hemagglutination inhibition (HI) titers, antibody binding and affinity maturation to individual hemagglutinin (HA) domains, HA1 and HA2, across vaccine platforms. Fold change in HI and antibody binding to HA1 trends higher for H1N1pdm09 and H3N2 but not against B strains in groups vaccinated with FluBlok compared with FluCelvax and Fluzone. Antibody-affinity maturation occurs against HA1 domain of H1N1pdm09, H3N2 and B following vaccination with all vaccine platforms, but not against H1N1pdm09-HA2. Importantly, prior year vaccination of subjects receiving repeat vaccinations demonstrated reduced antibody-affinity maturation to HA1 of all three influenza virus strains irrespective of the vaccine platform. This study identifies an important impact of repeat vaccination on antibody-affinity maturation following vaccination, which may contribute to lower vaccine effectiveness of seasonal influenza vaccines in humans
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spelling pubmed-66596792019-07-29 Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans Khurana, Surender Hahn, Megan Coyle, Elizabeth M. King, Lisa R. Lin, Tsai-Lien Treanor, John Sant, Andrea Golding, Hana Nat Commun Article Several vaccines are approved in the United States for seasonal influenza vaccination every year. Here we compare the impact of repeat influenza vaccination on hemagglutination inhibition (HI) titers, antibody binding and affinity maturation to individual hemagglutinin (HA) domains, HA1 and HA2, across vaccine platforms. Fold change in HI and antibody binding to HA1 trends higher for H1N1pdm09 and H3N2 but not against B strains in groups vaccinated with FluBlok compared with FluCelvax and Fluzone. Antibody-affinity maturation occurs against HA1 domain of H1N1pdm09, H3N2 and B following vaccination with all vaccine platforms, but not against H1N1pdm09-HA2. Importantly, prior year vaccination of subjects receiving repeat vaccinations demonstrated reduced antibody-affinity maturation to HA1 of all three influenza virus strains irrespective of the vaccine platform. This study identifies an important impact of repeat vaccination on antibody-affinity maturation following vaccination, which may contribute to lower vaccine effectiveness of seasonal influenza vaccines in humans Nature Publishing Group UK 2019-07-26 /pmc/articles/PMC6659679/ /pubmed/31350391 http://dx.doi.org/10.1038/s41467-019-11296-5 Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Khurana, Surender
Hahn, Megan
Coyle, Elizabeth M.
King, Lisa R.
Lin, Tsai-Lien
Treanor, John
Sant, Andrea
Golding, Hana
Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_full Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_fullStr Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_full_unstemmed Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_short Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_sort repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659679/
https://www.ncbi.nlm.nih.gov/pubmed/31350391
http://dx.doi.org/10.1038/s41467-019-11296-5
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