Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation

The infrapatellar fat pad (IFP) serves as a reservoir of Mesenchymal Stem Cells (MSC), and with adjacent synovium plays key roles in joint disease including the production of Substance P (SP) affecting local inflammatory responses and transmitting nociceptive signals. Here, we interrogate human IFP-...

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Detalles Bibliográficos
Autores principales: Kouroupis, Dimitrios, Bowles, Annie C., Willman, Melissa A., Perucca Orfei, Carlotta, Colombini, Alessandra, Best, Thomas M., Kaplan, Lee D., Correa, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659713/
https://www.ncbi.nlm.nih.gov/pubmed/31350444
http://dx.doi.org/10.1038/s41598-019-47391-2

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