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CD 36: Focus on Epigenetic and Post-Transcriptional Regulation
CD36 is a transmembrane protein involved in fatty acid translocation, scavenging for oxidized fatty acids acting as a receptor for adhesion molecules. It is expressed on macrophages, as well as other types of cells, such as endothelial and adipose cells. CD36 participates in muscle lipid uptake, adi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659770/ https://www.ncbi.nlm.nih.gov/pubmed/31379931 http://dx.doi.org/10.3389/fgene.2019.00680 |
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author | Niculite, Cristina-Mariana Enciu, Ana-Maria Hinescu, Mihail Eugen |
author_facet | Niculite, Cristina-Mariana Enciu, Ana-Maria Hinescu, Mihail Eugen |
author_sort | Niculite, Cristina-Mariana |
collection | PubMed |
description | CD36 is a transmembrane protein involved in fatty acid translocation, scavenging for oxidized fatty acids acting as a receptor for adhesion molecules. It is expressed on macrophages, as well as other types of cells, such as endothelial and adipose cells. CD36 participates in muscle lipid uptake, adipose energy storage, and gut fat absorption. Recently, several preclinical and clinical studies demonstrated that upregulation of CD36 is a prerequisite for tumor metastasis. Cancer metastasis-related research emerged much later and has been less investigated, though it is equally or even more important. CD36 protein expression can be modified by epigenetic changes and post-transcriptional interference from non-coding RNAs. Some data indicate modulation of CD36 expression in specific cell types by epigenetic changes via DNA methylation patterns or histone tails, or through miRNA interference, but this is largely unexplored. The few papers addressing this topic refer mostly to lipid metabolism-related pathologies, whereas in cancer research, data are even more scarce. The aim of this review was to summarize major epigenetic and post-transcriptional mechanisms that impact CD36 expression in relation to various pathologies while highlighting the areas in need of further exploration. |
format | Online Article Text |
id | pubmed-6659770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66597702019-08-02 CD 36: Focus on Epigenetic and Post-Transcriptional Regulation Niculite, Cristina-Mariana Enciu, Ana-Maria Hinescu, Mihail Eugen Front Genet Genetics CD36 is a transmembrane protein involved in fatty acid translocation, scavenging for oxidized fatty acids acting as a receptor for adhesion molecules. It is expressed on macrophages, as well as other types of cells, such as endothelial and adipose cells. CD36 participates in muscle lipid uptake, adipose energy storage, and gut fat absorption. Recently, several preclinical and clinical studies demonstrated that upregulation of CD36 is a prerequisite for tumor metastasis. Cancer metastasis-related research emerged much later and has been less investigated, though it is equally or even more important. CD36 protein expression can be modified by epigenetic changes and post-transcriptional interference from non-coding RNAs. Some data indicate modulation of CD36 expression in specific cell types by epigenetic changes via DNA methylation patterns or histone tails, or through miRNA interference, but this is largely unexplored. The few papers addressing this topic refer mostly to lipid metabolism-related pathologies, whereas in cancer research, data are even more scarce. The aim of this review was to summarize major epigenetic and post-transcriptional mechanisms that impact CD36 expression in relation to various pathologies while highlighting the areas in need of further exploration. Frontiers Media S.A. 2019-07-19 /pmc/articles/PMC6659770/ /pubmed/31379931 http://dx.doi.org/10.3389/fgene.2019.00680 Text en Copyright © 2019 Niculite, Enciu and Hinescu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Niculite, Cristina-Mariana Enciu, Ana-Maria Hinescu, Mihail Eugen CD 36: Focus on Epigenetic and Post-Transcriptional Regulation |
title | CD 36: Focus on Epigenetic and Post-Transcriptional Regulation |
title_full | CD 36: Focus on Epigenetic and Post-Transcriptional Regulation |
title_fullStr | CD 36: Focus on Epigenetic and Post-Transcriptional Regulation |
title_full_unstemmed | CD 36: Focus on Epigenetic and Post-Transcriptional Regulation |
title_short | CD 36: Focus on Epigenetic and Post-Transcriptional Regulation |
title_sort | cd 36: focus on epigenetic and post-transcriptional regulation |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659770/ https://www.ncbi.nlm.nih.gov/pubmed/31379931 http://dx.doi.org/10.3389/fgene.2019.00680 |
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