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CD 36: Focus on Epigenetic and Post-Transcriptional Regulation

CD36 is a transmembrane protein involved in fatty acid translocation, scavenging for oxidized fatty acids acting as a receptor for adhesion molecules. It is expressed on macrophages, as well as other types of cells, such as endothelial and adipose cells. CD36 participates in muscle lipid uptake, adi...

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Autores principales: Niculite, Cristina-Mariana, Enciu, Ana-Maria, Hinescu, Mihail Eugen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659770/
https://www.ncbi.nlm.nih.gov/pubmed/31379931
http://dx.doi.org/10.3389/fgene.2019.00680
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author Niculite, Cristina-Mariana
Enciu, Ana-Maria
Hinescu, Mihail Eugen
author_facet Niculite, Cristina-Mariana
Enciu, Ana-Maria
Hinescu, Mihail Eugen
author_sort Niculite, Cristina-Mariana
collection PubMed
description CD36 is a transmembrane protein involved in fatty acid translocation, scavenging for oxidized fatty acids acting as a receptor for adhesion molecules. It is expressed on macrophages, as well as other types of cells, such as endothelial and adipose cells. CD36 participates in muscle lipid uptake, adipose energy storage, and gut fat absorption. Recently, several preclinical and clinical studies demonstrated that upregulation of CD36 is a prerequisite for tumor metastasis. Cancer metastasis-related research emerged much later and has been less investigated, though it is equally or even more important. CD36 protein expression can be modified by epigenetic changes and post-transcriptional interference from non-coding RNAs. Some data indicate modulation of CD36 expression in specific cell types by epigenetic changes via DNA methylation patterns or histone tails, or through miRNA interference, but this is largely unexplored. The few papers addressing this topic refer mostly to lipid metabolism-related pathologies, whereas in cancer research, data are even more scarce. The aim of this review was to summarize major epigenetic and post-transcriptional mechanisms that impact CD36 expression in relation to various pathologies while highlighting the areas in need of further exploration.
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spelling pubmed-66597702019-08-02 CD 36: Focus on Epigenetic and Post-Transcriptional Regulation Niculite, Cristina-Mariana Enciu, Ana-Maria Hinescu, Mihail Eugen Front Genet Genetics CD36 is a transmembrane protein involved in fatty acid translocation, scavenging for oxidized fatty acids acting as a receptor for adhesion molecules. It is expressed on macrophages, as well as other types of cells, such as endothelial and adipose cells. CD36 participates in muscle lipid uptake, adipose energy storage, and gut fat absorption. Recently, several preclinical and clinical studies demonstrated that upregulation of CD36 is a prerequisite for tumor metastasis. Cancer metastasis-related research emerged much later and has been less investigated, though it is equally or even more important. CD36 protein expression can be modified by epigenetic changes and post-transcriptional interference from non-coding RNAs. Some data indicate modulation of CD36 expression in specific cell types by epigenetic changes via DNA methylation patterns or histone tails, or through miRNA interference, but this is largely unexplored. The few papers addressing this topic refer mostly to lipid metabolism-related pathologies, whereas in cancer research, data are even more scarce. The aim of this review was to summarize major epigenetic and post-transcriptional mechanisms that impact CD36 expression in relation to various pathologies while highlighting the areas in need of further exploration. Frontiers Media S.A. 2019-07-19 /pmc/articles/PMC6659770/ /pubmed/31379931 http://dx.doi.org/10.3389/fgene.2019.00680 Text en Copyright © 2019 Niculite, Enciu and Hinescu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Niculite, Cristina-Mariana
Enciu, Ana-Maria
Hinescu, Mihail Eugen
CD 36: Focus on Epigenetic and Post-Transcriptional Regulation
title CD 36: Focus on Epigenetic and Post-Transcriptional Regulation
title_full CD 36: Focus on Epigenetic and Post-Transcriptional Regulation
title_fullStr CD 36: Focus on Epigenetic and Post-Transcriptional Regulation
title_full_unstemmed CD 36: Focus on Epigenetic and Post-Transcriptional Regulation
title_short CD 36: Focus on Epigenetic and Post-Transcriptional Regulation
title_sort cd 36: focus on epigenetic and post-transcriptional regulation
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659770/
https://www.ncbi.nlm.nih.gov/pubmed/31379931
http://dx.doi.org/10.3389/fgene.2019.00680
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