Cargando…
The prognostic significance of SHP2 and its binding protein Hook1 in non-small cell lung cancer
BACKGROUND: We previously reported that Hook1 inhibits the phosphatase activity of SHP2 in the regulation of the epithelial-mesenchymal transition (EMT) in lung cancer. In this study, we performed a comprehensive analysis of SHP2 and Hook1 expression and relationships with the prognosis of patients...
Autores principales: | He, Lingjuan, Li, Yinyan, Huang, Xin, Cheng, Hongqiang, Ke, Yuehai, Wang, Linrun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659782/ https://www.ncbi.nlm.nih.gov/pubmed/31413587 http://dx.doi.org/10.2147/OTT.S210223 |
Ejemplares similares
-
SHP2 Positively Regulates TGFβ1-induced Epithelial-Mesenchymal Transition Modulated by Its Novel Interacting Protein Hook1
por: Li, Shuomin, et al.
Publicado: (2014) -
Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin
por: Zhang, Yuefei, et al.
Publicado: (2021) -
Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10
por: Xiao, Peng, et al.
Publicado: (2019) -
Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization
por: Xu, Zhiyong, et al.
Publicado: (2021) -
Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling
por: Liu, Pan, et al.
Publicado: (2022)