Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma

Cyclin-dependent kinase 9 (CDK9) transcriptionally regulates several proteins and cellular pathways central to radiation induced tissue injury. We investigated a role of BAY1143572, a new highly specific CDK9 inhibitor, as a sensitizer to radiation in esophageal adenocarcinoma. In vitro synergy betw...

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Detalles Bibliográficos
Autores principales: Veeranki, Omkara Lakshmi, Tong, Zhimin, Dokey, Rashmi, Mejia, Alicia, Zhang, Jianhu, Qiao, Yawei, Singh, Pankaj Kumar, Katkhuda, Riham, Mino, Barbara, Tailor, Ramesh, Canales, Jaime Rodriguez, Bassett, Roland, Ajani, Jaffer, Wu, Ji Yuan, Kopetz, Scott, Blum, Mariela, Hofstetter, Wayne, Tetzlaff, Michael, Krishnan, Sunil, Lin, Steven H., Maru, Dipen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659793/
https://www.ncbi.nlm.nih.gov/pubmed/31384397
http://dx.doi.org/10.18632/oncotarget.27095

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