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Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
BACKGROUND: Human papilloma virus (HPV) and tobacco smoking are important risk factors for development of oropharyngeal squamous cell carcinoma (OPSCC). AIMS/OBJECTIVES: To evaluate the impact of tobacco smoking on survival for cases with OPSCC with known HPV- and p16INK4A(p16)-status. MATERIALS AND...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659794/ https://www.ncbi.nlm.nih.gov/pubmed/31384393 http://dx.doi.org/10.18632/oncotarget.27079 |
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author | Grønhøj, Christian Jensen, Jakob Schmidt Wagner, Steffen Dehlendorff, Christian Friborg, Jeppe Andersen, Elo Wittekindt, Claus Würdemann, Nora Sharma, Shachi Jenny Gattenlöhner, Stefan Klussmann, Jens Peter von Buchwald, Christian |
author_facet | Grønhøj, Christian Jensen, Jakob Schmidt Wagner, Steffen Dehlendorff, Christian Friborg, Jeppe Andersen, Elo Wittekindt, Claus Würdemann, Nora Sharma, Shachi Jenny Gattenlöhner, Stefan Klussmann, Jens Peter von Buchwald, Christian |
author_sort | Grønhøj, Christian |
collection | PubMed |
description | BACKGROUND: Human papilloma virus (HPV) and tobacco smoking are important risk factors for development of oropharyngeal squamous cell carcinoma (OPSCC). AIMS/OBJECTIVES: To evaluate the impact of tobacco smoking on survival for cases with OPSCC with known HPV- and p16INK4A(p16)-status. MATERIALS AND METHODS: OPSCC cases at the University Hospital of Copenhagen, Rigshospitalet, Denmark (2000–2014) and at University Hospital of Giessen, Germany (2000–2009) were included. Survival was illustrated with Kaplan-Meier plots. The effect of smoking exposure on survival was evaluated by Cox-regression models. HPV-positivity was defined as positivity for both HPV-DNA and p16. RESULTS: We included 1316 OPSCC cases from 2000–2014 (48% HPV-positive). Smokers had a poorer outcome compared to non-smokers. Considering continuous smoking exposure, adding 10 pack-years of smoking increased hazard ratios irrespective of HPV-status. We observed a tendency to a greater impact on survival for cases with HPV-neg. tumours compared to cases with HPV-pos. tumours at low numbers of pack-years, yet the survival was similar at high numbers of pack-years. There was no significant difference in the impact of HPV-status on survival for non-smokers, however a highly significant difference for smokers. CONCLUSIONS AND SIGNIFICANCE: Smoking-status and number of pack-years at time of diagnosis impact survival for cases with OPSCC independent of HPV-status. |
format | Online Article Text |
id | pubmed-6659794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-66597942019-08-05 Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study Grønhøj, Christian Jensen, Jakob Schmidt Wagner, Steffen Dehlendorff, Christian Friborg, Jeppe Andersen, Elo Wittekindt, Claus Würdemann, Nora Sharma, Shachi Jenny Gattenlöhner, Stefan Klussmann, Jens Peter von Buchwald, Christian Oncotarget Research Paper BACKGROUND: Human papilloma virus (HPV) and tobacco smoking are important risk factors for development of oropharyngeal squamous cell carcinoma (OPSCC). AIMS/OBJECTIVES: To evaluate the impact of tobacco smoking on survival for cases with OPSCC with known HPV- and p16INK4A(p16)-status. MATERIALS AND METHODS: OPSCC cases at the University Hospital of Copenhagen, Rigshospitalet, Denmark (2000–2014) and at University Hospital of Giessen, Germany (2000–2009) were included. Survival was illustrated with Kaplan-Meier plots. The effect of smoking exposure on survival was evaluated by Cox-regression models. HPV-positivity was defined as positivity for both HPV-DNA and p16. RESULTS: We included 1316 OPSCC cases from 2000–2014 (48% HPV-positive). Smokers had a poorer outcome compared to non-smokers. Considering continuous smoking exposure, adding 10 pack-years of smoking increased hazard ratios irrespective of HPV-status. We observed a tendency to a greater impact on survival for cases with HPV-neg. tumours compared to cases with HPV-pos. tumours at low numbers of pack-years, yet the survival was similar at high numbers of pack-years. There was no significant difference in the impact of HPV-status on survival for non-smokers, however a highly significant difference for smokers. CONCLUSIONS AND SIGNIFICANCE: Smoking-status and number of pack-years at time of diagnosis impact survival for cases with OPSCC independent of HPV-status. Impact Journals LLC 2019-07-23 /pmc/articles/PMC6659794/ /pubmed/31384393 http://dx.doi.org/10.18632/oncotarget.27079 Text en Copyright: © 2019 Grønhøj et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Grønhøj, Christian Jensen, Jakob Schmidt Wagner, Steffen Dehlendorff, Christian Friborg, Jeppe Andersen, Elo Wittekindt, Claus Würdemann, Nora Sharma, Shachi Jenny Gattenlöhner, Stefan Klussmann, Jens Peter von Buchwald, Christian Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study |
title | Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study |
title_full | Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study |
title_fullStr | Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study |
title_full_unstemmed | Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study |
title_short | Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study |
title_sort | impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659794/ https://www.ncbi.nlm.nih.gov/pubmed/31384393 http://dx.doi.org/10.18632/oncotarget.27079 |
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