Cargando…

Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study

BACKGROUND: Human papilloma virus (HPV) and tobacco smoking are important risk factors for development of oropharyngeal squamous cell carcinoma (OPSCC). AIMS/OBJECTIVES: To evaluate the impact of tobacco smoking on survival for cases with OPSCC with known HPV- and p16INK4A(p16)-status. MATERIALS AND...

Descripción completa

Detalles Bibliográficos
Autores principales: Grønhøj, Christian, Jensen, Jakob Schmidt, Wagner, Steffen, Dehlendorff, Christian, Friborg, Jeppe, Andersen, Elo, Wittekindt, Claus, Würdemann, Nora, Sharma, Shachi Jenny, Gattenlöhner, Stefan, Klussmann, Jens Peter, von Buchwald, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659794/
https://www.ncbi.nlm.nih.gov/pubmed/31384393
http://dx.doi.org/10.18632/oncotarget.27079
_version_ 1783439200517881856
author Grønhøj, Christian
Jensen, Jakob Schmidt
Wagner, Steffen
Dehlendorff, Christian
Friborg, Jeppe
Andersen, Elo
Wittekindt, Claus
Würdemann, Nora
Sharma, Shachi Jenny
Gattenlöhner, Stefan
Klussmann, Jens Peter
von Buchwald, Christian
author_facet Grønhøj, Christian
Jensen, Jakob Schmidt
Wagner, Steffen
Dehlendorff, Christian
Friborg, Jeppe
Andersen, Elo
Wittekindt, Claus
Würdemann, Nora
Sharma, Shachi Jenny
Gattenlöhner, Stefan
Klussmann, Jens Peter
von Buchwald, Christian
author_sort Grønhøj, Christian
collection PubMed
description BACKGROUND: Human papilloma virus (HPV) and tobacco smoking are important risk factors for development of oropharyngeal squamous cell carcinoma (OPSCC). AIMS/OBJECTIVES: To evaluate the impact of tobacco smoking on survival for cases with OPSCC with known HPV- and p16INK4A(p16)-status. MATERIALS AND METHODS: OPSCC cases at the University Hospital of Copenhagen, Rigshospitalet, Denmark (2000–2014) and at University Hospital of Giessen, Germany (2000–2009) were included. Survival was illustrated with Kaplan-Meier plots. The effect of smoking exposure on survival was evaluated by Cox-regression models. HPV-positivity was defined as positivity for both HPV-DNA and p16. RESULTS: We included 1316 OPSCC cases from 2000–2014 (48% HPV-positive). Smokers had a poorer outcome compared to non-smokers. Considering continuous smoking exposure, adding 10 pack-years of smoking increased hazard ratios irrespective of HPV-status. We observed a tendency to a greater impact on survival for cases with HPV-neg. tumours compared to cases with HPV-pos. tumours at low numbers of pack-years, yet the survival was similar at high numbers of pack-years. There was no significant difference in the impact of HPV-status on survival for non-smokers, however a highly significant difference for smokers. CONCLUSIONS AND SIGNIFICANCE: Smoking-status and number of pack-years at time of diagnosis impact survival for cases with OPSCC independent of HPV-status.
format Online
Article
Text
id pubmed-6659794
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-66597942019-08-05 Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study Grønhøj, Christian Jensen, Jakob Schmidt Wagner, Steffen Dehlendorff, Christian Friborg, Jeppe Andersen, Elo Wittekindt, Claus Würdemann, Nora Sharma, Shachi Jenny Gattenlöhner, Stefan Klussmann, Jens Peter von Buchwald, Christian Oncotarget Research Paper BACKGROUND: Human papilloma virus (HPV) and tobacco smoking are important risk factors for development of oropharyngeal squamous cell carcinoma (OPSCC). AIMS/OBJECTIVES: To evaluate the impact of tobacco smoking on survival for cases with OPSCC with known HPV- and p16INK4A(p16)-status. MATERIALS AND METHODS: OPSCC cases at the University Hospital of Copenhagen, Rigshospitalet, Denmark (2000–2014) and at University Hospital of Giessen, Germany (2000–2009) were included. Survival was illustrated with Kaplan-Meier plots. The effect of smoking exposure on survival was evaluated by Cox-regression models. HPV-positivity was defined as positivity for both HPV-DNA and p16. RESULTS: We included 1316 OPSCC cases from 2000–2014 (48% HPV-positive). Smokers had a poorer outcome compared to non-smokers. Considering continuous smoking exposure, adding 10 pack-years of smoking increased hazard ratios irrespective of HPV-status. We observed a tendency to a greater impact on survival for cases with HPV-neg. tumours compared to cases with HPV-pos. tumours at low numbers of pack-years, yet the survival was similar at high numbers of pack-years. There was no significant difference in the impact of HPV-status on survival for non-smokers, however a highly significant difference for smokers. CONCLUSIONS AND SIGNIFICANCE: Smoking-status and number of pack-years at time of diagnosis impact survival for cases with OPSCC independent of HPV-status. Impact Journals LLC 2019-07-23 /pmc/articles/PMC6659794/ /pubmed/31384393 http://dx.doi.org/10.18632/oncotarget.27079 Text en Copyright: © 2019 Grønhøj et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Grønhøj, Christian
Jensen, Jakob Schmidt
Wagner, Steffen
Dehlendorff, Christian
Friborg, Jeppe
Andersen, Elo
Wittekindt, Claus
Würdemann, Nora
Sharma, Shachi Jenny
Gattenlöhner, Stefan
Klussmann, Jens Peter
von Buchwald, Christian
Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
title Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
title_full Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
title_fullStr Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
title_full_unstemmed Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
title_short Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
title_sort impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659794/
https://www.ncbi.nlm.nih.gov/pubmed/31384393
http://dx.doi.org/10.18632/oncotarget.27079
work_keys_str_mv AT grønhøjchristian impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT jensenjakobschmidt impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT wagnersteffen impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT dehlendorffchristian impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT friborgjeppe impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT andersenelo impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT wittekindtclaus impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT wurdemannnora impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT sharmashachijenny impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT gattenlohnerstefan impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT klussmannjenspeter impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy
AT vonbuchwaldchristian impactonsurvivaloftobaccosmokingforcaseswithoropharyngealsquamouscellcarcinomaandknownhumanpapillomavirusandp16statusamulticenterretrospectivestudy