Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury

Epigenetic mechanisms, such as DNA methylation, affect tubular maladaptive response after Acute Kidney Injury (AKI) and accelerate renal aging. Upon ischemia/reperfusion (I/R) injury, Complement activation leads to C5a release that mediates damage; however, little is known about the effect of C5a-C5...

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Detalles Bibliográficos
Autores principales: Castellano, Giuseppe, Franzin, Rossana, Sallustio, Fabio, Stasi, Alessandra, Banelli, Barbara, Romani, Massimo, De Palma, Giuseppe, Lucarelli, Giuseppe, Divella, Chiara, Battaglia, Michele, Crovace, Antonio, Staffieri, Francesco, Grandaliano, Giuseppe, Stallone, Giovanni, Ditonno, Pasquale, Cravedi, Paolo, Cantaluppi, Vincenzo, Gesualdo, Loreto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660044/
https://www.ncbi.nlm.nih.gov/pubmed/31284268
http://dx.doi.org/10.18632/aging.102059

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