Developmental dynamics of lncRNAs across mammalian organs and species

While many long noncoding RNAs (lncRNAs) have been identified in human and other mammalian genomes, there has been limited systematic functional characterization. In particular, the contribution of lncRNAs to organ development remains largely unexplored. Here we analyze the expression patterns of lncRNAs across developmental timepoints in seven major organs, from early organogenesis to adulthood, across seven species (human, macaque, mouse, rat, rabbit, opossum, and chicken). Our analyses identified ~15,000-35,000 candidate lncRNAs in each species, most of which show species specificity. We characterized expression patterns of lncRNAs across developmental stages, and found many with dynamic expression patterns across time that show signatures of enrichment for functionality. During development, there is a transition from broadly expressed and conserved lncRNAs towards an increasing number of lineage- and organ-specific lncRNAs. Our study provides a resource of candidate lncRNAs and their patterns of expression and evolutionary conservation across mammalian organ development.