TREM2 function impedes tau seeding in neuritic plaques

Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer’s disease (AD). Here we show that germline knockout of Trem2 or the TREM2(R47H) variant reduce microgliosis around amyloid-β (Aβ) plaques and facilitat...

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Autores principales: Leyns, Cheryl E.G., Gratuze, Maud, Narasimhan, Sneha, Jain, Nimansha, Koscal, Lauren J., Jiang, Hong, Manis, Melissa, Colonna, Marco, Lee, Virginia M.Y., Ulrich, Jason D., Holtzman, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660358/
https://www.ncbi.nlm.nih.gov/pubmed/31235932
http://dx.doi.org/10.1038/s41593-019-0433-0
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author Leyns, Cheryl E.G.
Gratuze, Maud
Narasimhan, Sneha
Jain, Nimansha
Koscal, Lauren J.
Jiang, Hong
Manis, Melissa
Colonna, Marco
Lee, Virginia M.Y.
Ulrich, Jason D.
Holtzman, David M.
author_facet Leyns, Cheryl E.G.
Gratuze, Maud
Narasimhan, Sneha
Jain, Nimansha
Koscal, Lauren J.
Jiang, Hong
Manis, Melissa
Colonna, Marco
Lee, Virginia M.Y.
Ulrich, Jason D.
Holtzman, David M.
author_sort Leyns, Cheryl E.G.
collection PubMed
description Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer’s disease (AD). Here we show that germline knockout of Trem2 or the TREM2(R47H) variant reduce microgliosis around amyloid-β (Aβ) plaques and facilitate the seeding and spreading of neuritic plaque (NP) tau aggregates. These findings demonstrate a key role for TREM2 and microglia in limiting development of peri-plaque tau pathologies.
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spelling pubmed-66603582019-12-24 TREM2 function impedes tau seeding in neuritic plaques Leyns, Cheryl E.G. Gratuze, Maud Narasimhan, Sneha Jain, Nimansha Koscal, Lauren J. Jiang, Hong Manis, Melissa Colonna, Marco Lee, Virginia M.Y. Ulrich, Jason D. Holtzman, David M. Nat Neurosci Article Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer’s disease (AD). Here we show that germline knockout of Trem2 or the TREM2(R47H) variant reduce microgliosis around amyloid-β (Aβ) plaques and facilitate the seeding and spreading of neuritic plaque (NP) tau aggregates. These findings demonstrate a key role for TREM2 and microglia in limiting development of peri-plaque tau pathologies. 2019-06-24 2019-08 /pmc/articles/PMC6660358/ /pubmed/31235932 http://dx.doi.org/10.1038/s41593-019-0433-0 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Leyns, Cheryl E.G.
Gratuze, Maud
Narasimhan, Sneha
Jain, Nimansha
Koscal, Lauren J.
Jiang, Hong
Manis, Melissa
Colonna, Marco
Lee, Virginia M.Y.
Ulrich, Jason D.
Holtzman, David M.
TREM2 function impedes tau seeding in neuritic plaques
title TREM2 function impedes tau seeding in neuritic plaques
title_full TREM2 function impedes tau seeding in neuritic plaques
title_fullStr TREM2 function impedes tau seeding in neuritic plaques
title_full_unstemmed TREM2 function impedes tau seeding in neuritic plaques
title_short TREM2 function impedes tau seeding in neuritic plaques
title_sort trem2 function impedes tau seeding in neuritic plaques
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660358/
https://www.ncbi.nlm.nih.gov/pubmed/31235932
http://dx.doi.org/10.1038/s41593-019-0433-0
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