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Hidden Markov models lead to higher resolution maps of mutation signature activity in cancer

Knowing the activity of the mutational processes shaping a cancer genome may provide insight into tumorigenesis and personalized therapy. It is thus important to characterize the signatures of active mutational processes in patients from their patterns of single base substitutions. However, mutation...

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Detalles Bibliográficos
Autores principales:	Wojtowicz, Damian, Sason, Itay, Huang, Xiaoqing, Kim, Yoo-Ah, Leiserson, Mark D. M., Przytycka, Teresa M., Sharan, Roded
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660659/ https://www.ncbi.nlm.nih.gov/pubmed/31349863 http://dx.doi.org/10.1186/s13073-019-0659-1

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