ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity

Giant ankyrin-B (ankB) is a neurospecific alternatively spliced variant of ANK2, a high-confidence autism spectrum disorder (ASD) gene. We report that a mouse model for human ASD mutation of giant ankB exhibits increased axonal branching in cultured neurons with ectopic CNS axon connectivity, as wel...

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Detalles Bibliográficos
Autores principales: Yang, Rui, Walder-Christensen, Kathryn K., Kim, Namsoo, Wu, Danwei, Lorenzo, Damaris N., Badea, Alexandra, Jiang, Yong-Hui, Yin, Henry H., Wetsel, William C., Bennett, Vann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660793/
https://www.ncbi.nlm.nih.gov/pubmed/31285321
http://dx.doi.org/10.1073/pnas.1904348116

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