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Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates

Although protein synthesis dynamics has been studied both with theoretical models and by profiling ribosome footprints, the determinants of ribosome flux along open reading frames (ORFs) are not fully understood. Combining measurements of protein synthesis rate with ribosome footprinting data, we he...

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Detalles Bibliográficos
Autores principales: Riba, Andrea, Di Nanni, Noemi, Mittal, Nitish, Arhné, Erik, Schmidt, Alexander, Zavolan, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660795/
https://www.ncbi.nlm.nih.gov/pubmed/31292258
http://dx.doi.org/10.1073/pnas.1817299116