Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease

Adipose tissue stores energy and is the largest endocrine organ in the body, producing several adipokines. However, among these adipokines, few play a role in the positive metabolism that promotes good health. Secreted frizzled-related protein (Sfrp)-5, an antagonist that directly binds to Wnt, has...

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Autores principales: Tong, Shan, Ji, Qingwei, Du, Yu, Zhu, Xiaogang, Zhu, Caizhong, Zhou, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660834/
https://www.ncbi.nlm.nih.gov/pubmed/31199714
http://dx.doi.org/10.1089/jir.2018.0154
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author Tong, Shan
Ji, Qingwei
Du, Yu
Zhu, Xiaogang
Zhu, Caizhong
Zhou, Yujie
author_facet Tong, Shan
Ji, Qingwei
Du, Yu
Zhu, Xiaogang
Zhu, Caizhong
Zhou, Yujie
author_sort Tong, Shan
collection PubMed
description Adipose tissue stores energy and is the largest endocrine organ in the body, producing several adipokines. However, among these adipokines, few play a role in the positive metabolism that promotes good health. Secreted frizzled-related protein (Sfrp)-5, an antagonist that directly binds to Wnt, has attracted interest due to its favorable effects on atherosclerotic cardiovascular disease (ASCVD). This review focuses on Sfrp5 biology and the roles of the Sfrp5/Wnt system in ASCVD.
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spelling pubmed-66608342019-07-30 Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease Tong, Shan Ji, Qingwei Du, Yu Zhu, Xiaogang Zhu, Caizhong Zhou, Yujie J Interferon Cytokine Res Review Adipose tissue stores energy and is the largest endocrine organ in the body, producing several adipokines. However, among these adipokines, few play a role in the positive metabolism that promotes good health. Secreted frizzled-related protein (Sfrp)-5, an antagonist that directly binds to Wnt, has attracted interest due to its favorable effects on atherosclerotic cardiovascular disease (ASCVD). This review focuses on Sfrp5 biology and the roles of the Sfrp5/Wnt system in ASCVD. Mary Ann Liebert, Inc., publishers 2019-08-01 2019-07-29 /pmc/articles/PMC6660834/ /pubmed/31199714 http://dx.doi.org/10.1089/jir.2018.0154 Text en © Shan Tong et al. 2019; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.
spellingShingle Review
Tong, Shan
Ji, Qingwei
Du, Yu
Zhu, Xiaogang
Zhu, Caizhong
Zhou, Yujie
Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease
title Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease
title_full Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease
title_fullStr Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease
title_full_unstemmed Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease
title_short Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease
title_sort sfrp5/wnt pathway: a protective regulatory system in atherosclerotic cardiovascular disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660834/
https://www.ncbi.nlm.nih.gov/pubmed/31199714
http://dx.doi.org/10.1089/jir.2018.0154
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