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Adverse reactions to antiretroviral therapy: a prevalent concern

The risk–benefit ratio of antiretroviral therapy (ART) is usually considered favorable due to the urgent need to control the HIV/AIDS epidemic. Current studies have shown that combined ART (two or more drugs, from two different classes) is the most effective, with benefits that go beyond clinical ma...

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Autores principales: de Pádua, Cristiane Menezes, Braga, Letícia Penna, Pinto Mendicino, Cássia Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Organización Panamericana de la Salud 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660853/
https://www.ncbi.nlm.nih.gov/pubmed/31391821
http://dx.doi.org/10.26633/RPSP.2017.84
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author de Pádua, Cristiane Menezes
Braga, Letícia Penna
Pinto Mendicino, Cássia Cristina
author_facet de Pádua, Cristiane Menezes
Braga, Letícia Penna
Pinto Mendicino, Cássia Cristina
author_sort de Pádua, Cristiane Menezes
collection PubMed
description The risk–benefit ratio of antiretroviral therapy (ART) is usually considered favorable due to the urgent need to control the HIV/AIDS epidemic. Current studies have shown that combined ART (two or more drugs, from two different classes) is the most effective, with benefits that go beyond clinical management of the disease playing a crucial role in preventing HIV transmission. Therefore, early identification of HIV infection followed by immediate initiation of ART has been encouraged worldwide. However, the success of this strategy has been threatened by poor engagement of patients in HIV care, which may be related to drug harms. In addition, ART is required for the life course, creating the potential for adverse drug reactions (e.g., lipodystrophies). Therefore, adverse drug reactions are a prevalent concern among people living with HIV/AIDS, even in the current era of early initiation of ART (“early ART”), with most drugs considered much safer than those used in previous eras. Accurate diagnosis, recording, and reporting, followed up with proper management and prevention, and intensive surveillance, of new and known adverse reactions to ART, should be strongly encouraged as part of the care continuum.
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spelling pubmed-66608532019-08-07 Adverse reactions to antiretroviral therapy: a prevalent concern de Pádua, Cristiane Menezes Braga, Letícia Penna Pinto Mendicino, Cássia Cristina Rev Panam Salud Publica Opinion and Analysis The risk–benefit ratio of antiretroviral therapy (ART) is usually considered favorable due to the urgent need to control the HIV/AIDS epidemic. Current studies have shown that combined ART (two or more drugs, from two different classes) is the most effective, with benefits that go beyond clinical management of the disease playing a crucial role in preventing HIV transmission. Therefore, early identification of HIV infection followed by immediate initiation of ART has been encouraged worldwide. However, the success of this strategy has been threatened by poor engagement of patients in HIV care, which may be related to drug harms. In addition, ART is required for the life course, creating the potential for adverse drug reactions (e.g., lipodystrophies). Therefore, adverse drug reactions are a prevalent concern among people living with HIV/AIDS, even in the current era of early initiation of ART (“early ART”), with most drugs considered much safer than those used in previous eras. Accurate diagnosis, recording, and reporting, followed up with proper management and prevention, and intensive surveillance, of new and known adverse reactions to ART, should be strongly encouraged as part of the care continuum. Organización Panamericana de la Salud 2017-06-19 /pmc/articles/PMC6660853/ /pubmed/31391821 http://dx.doi.org/10.26633/RPSP.2017.84 Text en https://creativecommons.org/licenses/by/4.0/  
spellingShingle Opinion and Analysis
de Pádua, Cristiane Menezes
Braga, Letícia Penna
Pinto Mendicino, Cássia Cristina
Adverse reactions to antiretroviral therapy: a prevalent concern
title Adverse reactions to antiretroviral therapy: a prevalent concern
title_full Adverse reactions to antiretroviral therapy: a prevalent concern
title_fullStr Adverse reactions to antiretroviral therapy: a prevalent concern
title_full_unstemmed Adverse reactions to antiretroviral therapy: a prevalent concern
title_short Adverse reactions to antiretroviral therapy: a prevalent concern
title_sort adverse reactions to antiretroviral therapy: a prevalent concern
topic Opinion and Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660853/
https://www.ncbi.nlm.nih.gov/pubmed/31391821
http://dx.doi.org/10.26633/RPSP.2017.84
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