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Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis

BACKGROUND: Gastric cancer (GC) is one of the most prevalent cancers with a high rate of mortality in the world. In recent years, microRNAs (miRNAs) have been proposed to be involved in GC development. In this study, we aimed at investigating differential expression level of miR-155-5p, miR-15a, miR...

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Autores principales: Zare, Ali, Alipoor, Behnam, Omrani, Mir Davood, Zali, Mohammad Reza, Malekpour Alamdari, Nasser, Ghaedi, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661124/
https://www.ncbi.nlm.nih.gov/pubmed/31103022
http://dx.doi.org/10.29252/.23.5.338
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author Zare, Ali
Alipoor, Behnam
Omrani, Mir Davood
Zali, Mohammad Reza
Malekpour Alamdari, Nasser
Ghaedi, Hamid
author_facet Zare, Ali
Alipoor, Behnam
Omrani, Mir Davood
Zali, Mohammad Reza
Malekpour Alamdari, Nasser
Ghaedi, Hamid
author_sort Zare, Ali
collection PubMed
description BACKGROUND: Gastric cancer (GC) is one of the most prevalent cancers with a high rate of mortality in the world. In recent years, microRNAs (miRNAs) have been proposed to be involved in GC development. In this study, we aimed at investigating differential expression level of miR-155-5p, miR-15a, miR-15b, and miR-186 in GC. METHODS: For this research, we used qPCR to investigate miR-15b, miR-155, miR-15a, and miR-186 expression levels in a total of 29 normal gastric tissue, 45 gastric dysplasia, and 39 GC samples. RESULTS: We showed significant down-regulation of miR-155-5p (p = 0.0018), miR-15a (p = 0.0159), and miR-186 (p = 0.0005) expression in GC tissue. CONCLUSION: This study provides evidence for deregulated expression of miR155-5p, miR-186, and miR-15a in GC and is providing new insights into the potential implication of these miRNAs in the pathogenesis of GC.  
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spelling pubmed-66611242019-09-01 Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis Zare, Ali Alipoor, Behnam Omrani, Mir Davood Zali, Mohammad Reza Malekpour Alamdari, Nasser Ghaedi, Hamid Iran Biomed J Full Length BACKGROUND: Gastric cancer (GC) is one of the most prevalent cancers with a high rate of mortality in the world. In recent years, microRNAs (miRNAs) have been proposed to be involved in GC development. In this study, we aimed at investigating differential expression level of miR-155-5p, miR-15a, miR-15b, and miR-186 in GC. METHODS: For this research, we used qPCR to investigate miR-15b, miR-155, miR-15a, and miR-186 expression levels in a total of 29 normal gastric tissue, 45 gastric dysplasia, and 39 GC samples. RESULTS: We showed significant down-regulation of miR-155-5p (p = 0.0018), miR-15a (p = 0.0159), and miR-186 (p = 0.0005) expression in GC tissue. CONCLUSION: This study provides evidence for deregulated expression of miR155-5p, miR-186, and miR-15a in GC and is providing new insights into the potential implication of these miRNAs in the pathogenesis of GC.   Pasteur Institute of Iran 2019-09 /pmc/articles/PMC6661124/ /pubmed/31103022 http://dx.doi.org/10.29252/.23.5.338 Text en © Iranian Biomedical Journal This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Length
Zare, Ali
Alipoor, Behnam
Omrani, Mir Davood
Zali, Mohammad Reza
Malekpour Alamdari, Nasser
Ghaedi, Hamid
Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis
title Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis
title_full Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis
title_fullStr Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis
title_full_unstemmed Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis
title_short Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis
title_sort decreased mir-155-5p, mir-15a, and mir-186 expression in gastric cancer is associated with advanced tumor grade and metastasis
topic Full Length
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661124/
https://www.ncbi.nlm.nih.gov/pubmed/31103022
http://dx.doi.org/10.29252/.23.5.338
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