FOXA1 mutations alter pioneering activity, differentiation, and prostate cancer phenotypes

Mutations in the FOXA1 transcription factor define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown(1-9). By annotating the FOXA1 mutation landscape from 3086 human prostate cancers, we define two hotsp...

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Detalles Bibliográficos
Autores principales: Adams, Elizabeth J., Karthaus, Wouter R., Hoover, Elizabeth, Liu, Deli, Gruet, Antoine, Zhang, Zeda, Cho, Hyunwoo, DiLoreto, Rose, Chhangawala, Sagar, Liu, Yang, Watson, Philip A., Davicioni, Elai, Sboner, Andrea, Barbieri, Christopher E., Bose, Rohit, Leslie, Christina S., Sawyers, Charles L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661172/
https://www.ncbi.nlm.nih.gov/pubmed/31243370
http://dx.doi.org/10.1038/s41586-019-1318-9

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