Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity

This data article is associated with the manuscript “GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity” [1]. The study refers to a combination of different approaches in order to id...

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Detalles Bibliográficos
Autores principales: Barrachina, María N., Izquierdo, Irene, Hermida-Nogueira, Lidia, Sueiro, Aurelio M., Guitián, Esteban, Casanueva, Felipe F., Farndale, Richard W., Moroi, Masaaki, Jung, Stephanie M., Pardo, María, García, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Biochemistry, Genetics and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661234/
https://www.ncbi.nlm.nih.gov/pubmed/31372431
http://dx.doi.org/10.1016/j.dib.2019.103784
Descripción
Sumario:This data article is associated with the manuscript “GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity” [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.

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