Inhibition of ubiquitin‐specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts

Ubiquitin‐specific protease 2 (USP2) is considered to participate in the differentiation of myoblasts to myotubes, however, its functions in myoblasts under growth conditions remain elusive. In this study, we analyzed the physiological roles of USP2 in myoblasts using Usp2 knockout (KO) C2C12 cells ...

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Detalles Bibliográficos
Autores principales: Hashimoto, Mayuko, Saito, Natsuko, Ohta, Haru, Yamamoto, Kumiko, Tashiro, Asuka, Nakazawa, Kosuke, Inanami, Osamu, Kitamura, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661303/
https://www.ncbi.nlm.nih.gov/pubmed/31353872
http://dx.doi.org/10.14814/phy2.14193

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