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A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis
The clinically reported case of liver involvement with multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Journal of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661521/ https://www.ncbi.nlm.nih.gov/pubmed/31439978 http://dx.doi.org/10.30476/IJMS.2019.44953 |
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author | Sadeghi, Alireza Nejati, Maliheh Moghaddas, Azadeh |
author_facet | Sadeghi, Alireza Nejati, Maliheh Moghaddas, Azadeh |
author_sort | Sadeghi, Alireza |
collection | PubMed |
description | The clinically reported case of liver involvement with multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure and biliary system involvement due to amyloidosis. Our patient had the primal symptoms of hyperbilirubinemia, ascites, hepatosplenomegaly, and anemia. Chemotherapy with a standard regimen containing bortezomib, thalidomide, and dexamethasone was implemented and led to a dramatic response. Liver involvement due to light chain amyloidosis can be the first drastic presentation of MM. It is important to consider infiltrative disorders, like MM and amyloidosis, when patients present non-specific symptoms and impaired liver function tests. Proper and timely diagnosis can directly affect the prognosis of patients. The optimal approach in the standard management of similar cases is still a matter of debate. |
format | Online Article Text |
id | pubmed-6661521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Iranian Journal of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-66615212019-08-22 A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis Sadeghi, Alireza Nejati, Maliheh Moghaddas, Azadeh Iran J Med Sci Case Reports The clinically reported case of liver involvement with multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure and biliary system involvement due to amyloidosis. Our patient had the primal symptoms of hyperbilirubinemia, ascites, hepatosplenomegaly, and anemia. Chemotherapy with a standard regimen containing bortezomib, thalidomide, and dexamethasone was implemented and led to a dramatic response. Liver involvement due to light chain amyloidosis can be the first drastic presentation of MM. It is important to consider infiltrative disorders, like MM and amyloidosis, when patients present non-specific symptoms and impaired liver function tests. Proper and timely diagnosis can directly affect the prognosis of patients. The optimal approach in the standard management of similar cases is still a matter of debate. Iranian Journal of Medical Sciences 2019-07 /pmc/articles/PMC6661521/ /pubmed/31439978 http://dx.doi.org/10.30476/IJMS.2019.44953 Text en Copyright: © Iranian Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Sadeghi, Alireza Nejati, Maliheh Moghaddas, Azadeh A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis |
title | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis
|
title_full | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis
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title_fullStr | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis
|
title_full_unstemmed | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis
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title_short | A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis
|
title_sort | rare presentation of multiple myeloma: a case report of hepatic amyloidosis |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661521/ https://www.ncbi.nlm.nih.gov/pubmed/31439978 http://dx.doi.org/10.30476/IJMS.2019.44953 |
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