Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury

BACKGROUND: Spinal cord injury (SCI) is a catastrophic trauma accompanied by intralesional bleeding and neuroinflammation. Recently, there is increasing interest in tranexamic acid (TXA), an anti-fibrinolytic drug, which can reduce the bleeding volume after physical trauma. However, the efficacy of...

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Detalles Bibliográficos
Autores principales: Yoshizaki, Shingo, Kijima, Ken, Hara, Masamitsu, Saito, Takeyuki, Tamaru, Tetsuya, Tanaka, Masatake, Konno, Dai-jiro, Nakashima, Yasuharu, Okada, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661785/
https://www.ncbi.nlm.nih.gov/pubmed/31358003
http://dx.doi.org/10.1186/s12974-019-1536-y

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