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4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation

BACKGROUND: Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have be...

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Detalles Bibliográficos
Autores principales:	Tahlan, Sumit, Ramasamy, Kalavathy, Lim, Siong Meng, Shah, Syed Adnan Ali, Mani, Vasudevan, Narasimhan, Balasubramanian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661798/ https://www.ncbi.nlm.nih.gov/pubmed/31384761 http://dx.doi.org/10.1186/s13065-019-0533-7

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