Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019)

In article number of 1801995, Chae‐Ok Yun, Yeu‐Chun Kim, and co‐workers develop helical polypeptide‐based potassium ionophores that can drive out potassium ions from the cytosol. The perturbed potassium homeostasis strongly inflicts endoplasmic reticulum stress to cells and then creates severe oxida...

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Autores principales: Lee, DaeYong, Lee, Soo‐Hwan, Noh, Ilkoo, Oh, Eonju, Ryu, Hyunil, Ha, JongHoon, Jeong, SeongDong, Yoo, Jisang, Jeon, Tae‐Joon, Yun, Chae‐Ok, Kim, Yeu‐Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661932/
http://dx.doi.org/10.1002/advs.201970087
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author Lee, DaeYong
Lee, Soo‐Hwan
Noh, Ilkoo
Oh, Eonju
Ryu, Hyunil
Ha, JongHoon
Jeong, SeongDong
Yoo, Jisang
Jeon, Tae‐Joon
Yun, Chae‐Ok
Kim, Yeu‐Chun
author_facet Lee, DaeYong
Lee, Soo‐Hwan
Noh, Ilkoo
Oh, Eonju
Ryu, Hyunil
Ha, JongHoon
Jeong, SeongDong
Yoo, Jisang
Jeon, Tae‐Joon
Yun, Chae‐Ok
Kim, Yeu‐Chun
author_sort Lee, DaeYong
collection PubMed
description In article number of 1801995, Chae‐Ok Yun, Yeu‐Chun Kim, and co‐workers develop helical polypeptide‐based potassium ionophores that can drive out potassium ions from the cytosol. The perturbed potassium homeostasis strongly inflicts endoplasmic reticulum stress to cells and then creates severe oxidative environments, thereby triggering apoptosis. The novel potassium ionophore will be used as a new anticancer agent. [Image: see text]
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spelling pubmed-66619322019-08-02 Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019) Lee, DaeYong Lee, Soo‐Hwan Noh, Ilkoo Oh, Eonju Ryu, Hyunil Ha, JongHoon Jeong, SeongDong Yoo, Jisang Jeon, Tae‐Joon Yun, Chae‐Ok Kim, Yeu‐Chun Adv Sci (Weinh) Back Cover In article number of 1801995, Chae‐Ok Yun, Yeu‐Chun Kim, and co‐workers develop helical polypeptide‐based potassium ionophores that can drive out potassium ions from the cytosol. The perturbed potassium homeostasis strongly inflicts endoplasmic reticulum stress to cells and then creates severe oxidative environments, thereby triggering apoptosis. The novel potassium ionophore will be used as a new anticancer agent. [Image: see text] John Wiley and Sons Inc. 2019-07-17 /pmc/articles/PMC6661932/ http://dx.doi.org/10.1002/advs.201970087 Text en © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Back Cover
Lee, DaeYong
Lee, Soo‐Hwan
Noh, Ilkoo
Oh, Eonju
Ryu, Hyunil
Ha, JongHoon
Jeong, SeongDong
Yoo, Jisang
Jeon, Tae‐Joon
Yun, Chae‐Ok
Kim, Yeu‐Chun
Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019)
title Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019)
title_full Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019)
title_fullStr Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019)
title_full_unstemmed Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019)
title_short Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019)
title_sort drug development: a helical polypeptide‐based potassium ionophore induces endoplasmic reticulum stress‐mediated apoptosis by perturbing ion homeostasis (adv. sci. 14/2019)
topic Back Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661932/
http://dx.doi.org/10.1002/advs.201970087
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