Indole bearing thiadiazole analogs: synthesis, β-glucuronidase inhibition and molecular docking study

Indole based thiadiazole derivatives (1–22) have synthesized, characterized by NMR and HREI-MS and evaluated for β-Glucuronidase inhibition. All compounds showed outstanding β-glucuronidase activity with IC(50) values ranging between 0.5 ± 0.08 to 38.9 ± 0.8 µM when compared with standard d-sacchari...

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Detalles Bibliográficos
Autores principales: Almandil, Noor Barak, Taha, Muhammad, Gollapalli, Mohammed, Rahim, Fazal, Ibrahim, Mohamed, Mosaddik, Ashik, Anouar, El Hassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661955/
https://www.ncbi.nlm.nih.gov/pubmed/31384763
http://dx.doi.org/10.1186/s13065-019-0522-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661955/
https://www.ncbi.nlm.nih.gov/pubmed/31384763
http://dx.doi.org/10.1186/s13065-019-0522-x

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