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Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population

Backgroud and objectives: Although lung attenuation distribution and lung volume on computed tomography (CT) have been widely used in evaluating COPD and interstitial lung disease, there are only a few studies regarding the normal range of these indices, especially in Chinese subjects. We aimed to d...

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Autores principales: Cheng, Ting, Li, Yong, Pang, Shuai, Wan, HuanYing, Shi, GuoChao, Cheng, QiJian, Li, QingYun, Pan, ZiLai, Huang, ShaoGuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662163/
https://www.ncbi.nlm.nih.gov/pubmed/31413560
http://dx.doi.org/10.2147/COPD.S187596
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author Cheng, Ting
Li, Yong
Pang, Shuai
Wan, HuanYing
Shi, GuoChao
Cheng, QiJian
Li, QingYun
Pan, ZiLai
Huang, ShaoGuang
author_facet Cheng, Ting
Li, Yong
Pang, Shuai
Wan, HuanYing
Shi, GuoChao
Cheng, QiJian
Li, QingYun
Pan, ZiLai
Huang, ShaoGuang
author_sort Cheng, Ting
collection PubMed
description Backgroud and objectives: Although lung attenuation distribution and lung volume on computed tomography (CT) have been widely used in evaluating COPD and interstitial lung disease, there are only a few studies regarding the normal range of these indices, especially in Chinese subjects. We aimed to describe the normal range of lung attenuation distribution and lung volume based on CT. Methods: Subjects with normal lung function and basically normal chest CT findings (derivation group) at Ruijin Hospital, Shanghai (from January 2010 to June 2014) were included according to inclusion and exclusion criteria. The range of the percentage of lung volume occupied by low attenuation areas (LAA%), percentile of the histogram of attenuation values (Perc n), and total lung volume were analyzed. Relationships of these measures with demographic variables were evaluated. Participants who underwent chest CT examination for disease screening and had basically normal CT findings served as an external validation group. Results: The number of subjects in the derivation group and external validation groups were 564 and 1,787, respectively. Mean total lung volumes were 4,468±1,271 mL and 4,668±1,192 mL, and median LAA%(-950 HU) was 0.19 (0.03–0.43) and 0.17 (0.01–0.41), in the derivation and external validation groups, respectively. Reference equations for lung volume and attenuation distribution (LAA% using -1,000–210 HU, Perc 1 to Perc 98) were generated: Lung volume (mL) = -1.015 *10^4+605.3*Sex (1= male, 0= female)+92.61*Height (cm) –12.99*Weight (kg) ±1766; LAA% (-950 HU)=[0.2027+0.05926*Sex (1= male, 0= female) –4.111*10^-3*Weight (kg) +4.924*10^-3*Height (cm) +8.504*10^-4*Age]^7.341–0.05; Upper limit of normal range: [0.2027+0.05926*Sex-4.111*10^-3*Weight+4.924*10^-3*Height+8.504*10^-4*Age+0.1993]^7.341–0.05. Conclusion: This large population-based retrospective study demonstrated the normal range of LAA%, Perc n, and total lung volume measured on CT scans among subjects with normal lung function and CT findings. Reference equations are provided.
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spelling pubmed-66621632019-08-14 Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population Cheng, Ting Li, Yong Pang, Shuai Wan, HuanYing Shi, GuoChao Cheng, QiJian Li, QingYun Pan, ZiLai Huang, ShaoGuang Int J Chron Obstruct Pulmon Dis Original Research Backgroud and objectives: Although lung attenuation distribution and lung volume on computed tomography (CT) have been widely used in evaluating COPD and interstitial lung disease, there are only a few studies regarding the normal range of these indices, especially in Chinese subjects. We aimed to describe the normal range of lung attenuation distribution and lung volume based on CT. Methods: Subjects with normal lung function and basically normal chest CT findings (derivation group) at Ruijin Hospital, Shanghai (from January 2010 to June 2014) were included according to inclusion and exclusion criteria. The range of the percentage of lung volume occupied by low attenuation areas (LAA%), percentile of the histogram of attenuation values (Perc n), and total lung volume were analyzed. Relationships of these measures with demographic variables were evaluated. Participants who underwent chest CT examination for disease screening and had basically normal CT findings served as an external validation group. Results: The number of subjects in the derivation group and external validation groups were 564 and 1,787, respectively. Mean total lung volumes were 4,468±1,271 mL and 4,668±1,192 mL, and median LAA%(-950 HU) was 0.19 (0.03–0.43) and 0.17 (0.01–0.41), in the derivation and external validation groups, respectively. Reference equations for lung volume and attenuation distribution (LAA% using -1,000–210 HU, Perc 1 to Perc 98) were generated: Lung volume (mL) = -1.015 *10^4+605.3*Sex (1= male, 0= female)+92.61*Height (cm) –12.99*Weight (kg) ±1766; LAA% (-950 HU)=[0.2027+0.05926*Sex (1= male, 0= female) –4.111*10^-3*Weight (kg) +4.924*10^-3*Height (cm) +8.504*10^-4*Age]^7.341–0.05; Upper limit of normal range: [0.2027+0.05926*Sex-4.111*10^-3*Weight+4.924*10^-3*Height+8.504*10^-4*Age+0.1993]^7.341–0.05. Conclusion: This large population-based retrospective study demonstrated the normal range of LAA%, Perc n, and total lung volume measured on CT scans among subjects with normal lung function and CT findings. Reference equations are provided. Dove 2019-07-24 /pmc/articles/PMC6662163/ /pubmed/31413560 http://dx.doi.org/10.2147/COPD.S187596 Text en © 2019 Cheng et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Cheng, Ting
Li, Yong
Pang, Shuai
Wan, HuanYing
Shi, GuoChao
Cheng, QiJian
Li, QingYun
Pan, ZiLai
Huang, ShaoGuang
Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population
title Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population
title_full Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population
title_fullStr Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population
title_full_unstemmed Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population
title_short Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population
title_sort normal lung attenuation distribution and lung volume on computed tomography in a chinese population
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662163/
https://www.ncbi.nlm.nih.gov/pubmed/31413560
http://dx.doi.org/10.2147/COPD.S187596
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