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Association between single nucleotide polymorphisms of NOTCH signaling pathway-related genes and the prognosis of NSCLC

OBJECTIVE: In this study, we analyzed the association between genetic variants of genes in the NOTCH signaling pathway and the prognosis of non-small-cell lung cancer (NSCLC) in the Chinese population. We also explored the interaction between genetic and epidemiological factors for the test group. M...

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Autores principales: Xu, Qiuping, Lin, Danhua, Li, Xu, Xiao, Rendong, Liu, Zhiqiang, Xiong, Weimin, Cai, Lin, He, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662170/
https://www.ncbi.nlm.nih.gov/pubmed/31413635
http://dx.doi.org/10.2147/CMAR.S197747
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author Xu, Qiuping
Lin, Danhua
Li, Xu
Xiao, Rendong
Liu, Zhiqiang
Xiong, Weimin
Cai, Lin
He, Fei
author_facet Xu, Qiuping
Lin, Danhua
Li, Xu
Xiao, Rendong
Liu, Zhiqiang
Xiong, Weimin
Cai, Lin
He, Fei
author_sort Xu, Qiuping
collection PubMed
description OBJECTIVE: In this study, we analyzed the association between genetic variants of genes in the NOTCH signaling pathway and the prognosis of non-small-cell lung cancer (NSCLC) in the Chinese population. We also explored the interaction between genetic and epidemiological factors for the test group. METHODS: We performed genotyping of 987 NSCLC patients. Then, we used Cox proportional hazard models to analyze the associations between single-nucleotide polymorphisms (SNPs) and the prognosis of NSCLC. We employed Stata software to test the heterogeneity of associations between subgroups, and we analyzed the additive and multiplicative interactions between SNPs and epidemiologic factors. RESULTS: This work revealed the important prognostic and predictive value of rs915894 in the NOTCH4 gene, which may be regarded as a promising prognosis biomarker of NSCLC. Cox regression analysis indicated that the C allele of rs915894 is associated with longer survival and decreased risk of death in NSCLC (codominant model: adjusted HR =0.83, 95% CI =0.70–0.99; dominant model: adjusted HR =0.83, 95% CI =0.71–0.98). Additional stepwise regression analysis suggested that this SNP is an independently favorable factor for the prognosis of NSCLC (dominant model: adjusted HR =0.85, 95% CI =0.72–0.99). This protective effect is more pronounced for patients who are not smokers, have a history of other lung diseases, or have a family history of cancer. We also detected statistically significant additive and multiplicative interactions between rs915894 and smoking, rs915894 and history of lung diseases, and rs915894 and family history of cancer, which all affect NSCLC survival. CONCLUSION: This study demonstrated that rs915894 in NOTCH4 may be a genetic marker for NSCLC prognosis in the Chinese population and that rs915894 may have an interactive relationship with epidemiologic factors.
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spelling pubmed-66621702019-08-14 Association between single nucleotide polymorphisms of NOTCH signaling pathway-related genes and the prognosis of NSCLC Xu, Qiuping Lin, Danhua Li, Xu Xiao, Rendong Liu, Zhiqiang Xiong, Weimin Cai, Lin He, Fei Cancer Manag Res Original Research OBJECTIVE: In this study, we analyzed the association between genetic variants of genes in the NOTCH signaling pathway and the prognosis of non-small-cell lung cancer (NSCLC) in the Chinese population. We also explored the interaction between genetic and epidemiological factors for the test group. METHODS: We performed genotyping of 987 NSCLC patients. Then, we used Cox proportional hazard models to analyze the associations between single-nucleotide polymorphisms (SNPs) and the prognosis of NSCLC. We employed Stata software to test the heterogeneity of associations between subgroups, and we analyzed the additive and multiplicative interactions between SNPs and epidemiologic factors. RESULTS: This work revealed the important prognostic and predictive value of rs915894 in the NOTCH4 gene, which may be regarded as a promising prognosis biomarker of NSCLC. Cox regression analysis indicated that the C allele of rs915894 is associated with longer survival and decreased risk of death in NSCLC (codominant model: adjusted HR =0.83, 95% CI =0.70–0.99; dominant model: adjusted HR =0.83, 95% CI =0.71–0.98). Additional stepwise regression analysis suggested that this SNP is an independently favorable factor for the prognosis of NSCLC (dominant model: adjusted HR =0.85, 95% CI =0.72–0.99). This protective effect is more pronounced for patients who are not smokers, have a history of other lung diseases, or have a family history of cancer. We also detected statistically significant additive and multiplicative interactions between rs915894 and smoking, rs915894 and history of lung diseases, and rs915894 and family history of cancer, which all affect NSCLC survival. CONCLUSION: This study demonstrated that rs915894 in NOTCH4 may be a genetic marker for NSCLC prognosis in the Chinese population and that rs915894 may have an interactive relationship with epidemiologic factors. Dove 2019-07-24 /pmc/articles/PMC6662170/ /pubmed/31413635 http://dx.doi.org/10.2147/CMAR.S197747 Text en © 2019 Xu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Xu, Qiuping
Lin, Danhua
Li, Xu
Xiao, Rendong
Liu, Zhiqiang
Xiong, Weimin
Cai, Lin
He, Fei
Association between single nucleotide polymorphisms of NOTCH signaling pathway-related genes and the prognosis of NSCLC
title Association between single nucleotide polymorphisms of NOTCH signaling pathway-related genes and the prognosis of NSCLC
title_full Association between single nucleotide polymorphisms of NOTCH signaling pathway-related genes and the prognosis of NSCLC
title_fullStr Association between single nucleotide polymorphisms of NOTCH signaling pathway-related genes and the prognosis of NSCLC
title_full_unstemmed Association between single nucleotide polymorphisms of NOTCH signaling pathway-related genes and the prognosis of NSCLC
title_short Association between single nucleotide polymorphisms of NOTCH signaling pathway-related genes and the prognosis of NSCLC
title_sort association between single nucleotide polymorphisms of notch signaling pathway-related genes and the prognosis of nsclc
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662170/
https://www.ncbi.nlm.nih.gov/pubmed/31413635
http://dx.doi.org/10.2147/CMAR.S197747
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