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Downregulation of Orexin Receptor in Hypothalamic Paraventricular Nucleus Decreases Blood Pressure in Obese Zucker Rats

BACKGROUND: Orexin and its receptors are critical regulating sympathetic vasomotor tone under physiological and pathophysiological conditions. Orexin receptor 1 (OXR1) is upregulated in the paraventricular nucleus (PVN) in the hypothalamus and contributes to increased sympathetic outflow in obese Zu...

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Detalles Bibliográficos
Autores principales:	Zhou, Jing‐Jing, Ma, Hui‐Jie, Shao, Jianying, Wei, Yan, Zhang, Xiangjian, Zhang, Yi, Li, De‐Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662376/ https://www.ncbi.nlm.nih.gov/pubmed/31213116 http://dx.doi.org/10.1161/JAHA.118.011434

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