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The Mechanical Interpretation of Ocular Response Analyzer Parameters

PURPOSE: Ocular Response Analyzer (ORA) is one of the most widely used devices in clinic, while the mechanical interpretations of parameters obtained from ORA have not been understood completely. The aim of this research is to explore the mechanical interpretation of ORA parameters. METHODS: Rabbits...

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Autores principales: Qin, Xiao, Yu, Mengyao, Zhang, Haixia, Chen, Xinyan, Li, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662474/
https://www.ncbi.nlm.nih.gov/pubmed/31380431
http://dx.doi.org/10.1155/2019/5701236
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author Qin, Xiao
Yu, Mengyao
Zhang, Haixia
Chen, Xinyan
Li, Lin
author_facet Qin, Xiao
Yu, Mengyao
Zhang, Haixia
Chen, Xinyan
Li, Lin
author_sort Qin, Xiao
collection PubMed
description PURPOSE: Ocular Response Analyzer (ORA) is one of the most widely used devices in clinic, while the mechanical interpretations of parameters obtained from ORA have not been understood completely. The aim of this research is to explore the mechanical interpretation of ORA parameters. METHODS: Rabbits aged 3-24 months were measured with ORA in vivo and corneal strips uniaxial tensile tests to get ORA parameters and corneal biomechanical parameters (corneal elastic modulus, relaxation time, and relaxation limit). The mechanical interpretation of ORA parameters was cognized preliminarily by analyzing the correlation between ORA parameters and corneal biomechanical parameters. On the other hand, finite element method was applied to simulate ORA measurements with different corneal biomechanical parameters to obtain quantitative relationship between ORA parameters and corneal biomechanical parameters further. RESULTS: Biomechanical experimental results showed that Corneal Resistance Factor (CRF) was correlated with corneal elastic modulus and relaxation limit significantly, while the significant correlations between Corneal Hysteresis (CH) and corneal biomechanical parameters were not observed. Results of finite element analysis showed that both CH and CRF were correlated with corneal elastic modulus, relaxation limit, and relaxation time significantly. Besides, corneal elastic modulus was positively correlated with upslop1 and upslop2 and negatively correlated with w2. CONCLUSIONS: For all ORA parameters, CH, CRF, the upslope, and the width of the peaks are parameters which may reflect corneal elastic properties. It is viable to cognize mechanical interpretation of ORA parameters by the comparisons of the data from ORA and biomechanical tests of rabbits with different ages and the simulations of ORA based on finite element methods. Further studies are needed to confirm the mechanical interpretation.
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spelling pubmed-66624742019-08-04 The Mechanical Interpretation of Ocular Response Analyzer Parameters Qin, Xiao Yu, Mengyao Zhang, Haixia Chen, Xinyan Li, Lin Biomed Res Int Research Article PURPOSE: Ocular Response Analyzer (ORA) is one of the most widely used devices in clinic, while the mechanical interpretations of parameters obtained from ORA have not been understood completely. The aim of this research is to explore the mechanical interpretation of ORA parameters. METHODS: Rabbits aged 3-24 months were measured with ORA in vivo and corneal strips uniaxial tensile tests to get ORA parameters and corneal biomechanical parameters (corneal elastic modulus, relaxation time, and relaxation limit). The mechanical interpretation of ORA parameters was cognized preliminarily by analyzing the correlation between ORA parameters and corneal biomechanical parameters. On the other hand, finite element method was applied to simulate ORA measurements with different corneal biomechanical parameters to obtain quantitative relationship between ORA parameters and corneal biomechanical parameters further. RESULTS: Biomechanical experimental results showed that Corneal Resistance Factor (CRF) was correlated with corneal elastic modulus and relaxation limit significantly, while the significant correlations between Corneal Hysteresis (CH) and corneal biomechanical parameters were not observed. Results of finite element analysis showed that both CH and CRF were correlated with corneal elastic modulus, relaxation limit, and relaxation time significantly. Besides, corneal elastic modulus was positively correlated with upslop1 and upslop2 and negatively correlated with w2. CONCLUSIONS: For all ORA parameters, CH, CRF, the upslope, and the width of the peaks are parameters which may reflect corneal elastic properties. It is viable to cognize mechanical interpretation of ORA parameters by the comparisons of the data from ORA and biomechanical tests of rabbits with different ages and the simulations of ORA based on finite element methods. Further studies are needed to confirm the mechanical interpretation. Hindawi 2019-07-16 /pmc/articles/PMC6662474/ /pubmed/31380431 http://dx.doi.org/10.1155/2019/5701236 Text en Copyright © 2019 Xiao Qin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Qin, Xiao
Yu, Mengyao
Zhang, Haixia
Chen, Xinyan
Li, Lin
The Mechanical Interpretation of Ocular Response Analyzer Parameters
title The Mechanical Interpretation of Ocular Response Analyzer Parameters
title_full The Mechanical Interpretation of Ocular Response Analyzer Parameters
title_fullStr The Mechanical Interpretation of Ocular Response Analyzer Parameters
title_full_unstemmed The Mechanical Interpretation of Ocular Response Analyzer Parameters
title_short The Mechanical Interpretation of Ocular Response Analyzer Parameters
title_sort mechanical interpretation of ocular response analyzer parameters
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662474/
https://www.ncbi.nlm.nih.gov/pubmed/31380431
http://dx.doi.org/10.1155/2019/5701236
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