Cargando…

Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering

Tissue engineering embraces the potential of recreating and replacing defective body parts by advancements in the medical field. Being a biocompatible nanomaterial with outstanding physical, chemical, optical, and biological properties, graphene-based materials were successfully employed in creating...

Descripción completa

Detalles Bibliográficos
Autores principales: Geetha Bai, Renu, Muthoosamy, Kasturi, Manickam, Sivakumar, Hilal-Alnaqbi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662516/
https://www.ncbi.nlm.nih.gov/pubmed/31413573
http://dx.doi.org/10.2147/IJN.S192779
_version_ 1783439670547316736
author Geetha Bai, Renu
Muthoosamy, Kasturi
Manickam, Sivakumar
Hilal-Alnaqbi, Ali
author_facet Geetha Bai, Renu
Muthoosamy, Kasturi
Manickam, Sivakumar
Hilal-Alnaqbi, Ali
author_sort Geetha Bai, Renu
collection PubMed
description Tissue engineering embraces the potential of recreating and replacing defective body parts by advancements in the medical field. Being a biocompatible nanomaterial with outstanding physical, chemical, optical, and biological properties, graphene-based materials were successfully employed in creating the perfect scaffold for a range of organs, starting from the skin through to the brain. Investigations on 2D and 3D tissue culture scaffolds incorporated with graphene or its derivatives have revealed the capability of this carbon material in mimicking in vivo environment. The porous morphology, great surface area, selective permeability of gases, excellent mechanical strength, good thermal and electrical conductivity, good optical properties, and biodegradability enable graphene materials to be the best component for scaffold engineering. Along with the apt microenvironment, this material was found to be efficient in differentiating stem cells into specific cell types. Furthermore, the scope of graphene nanomaterials in liver tissue engineering as a promising biomaterial is also discussed. This review critically looks into the unlimited potential of graphene-based nanomaterials in future tissue engineering and regenerative therapy.
format Online
Article
Text
id pubmed-6662516
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-66625162019-08-14 Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering Geetha Bai, Renu Muthoosamy, Kasturi Manickam, Sivakumar Hilal-Alnaqbi, Ali Int J Nanomedicine Review Tissue engineering embraces the potential of recreating and replacing defective body parts by advancements in the medical field. Being a biocompatible nanomaterial with outstanding physical, chemical, optical, and biological properties, graphene-based materials were successfully employed in creating the perfect scaffold for a range of organs, starting from the skin through to the brain. Investigations on 2D and 3D tissue culture scaffolds incorporated with graphene or its derivatives have revealed the capability of this carbon material in mimicking in vivo environment. The porous morphology, great surface area, selective permeability of gases, excellent mechanical strength, good thermal and electrical conductivity, good optical properties, and biodegradability enable graphene materials to be the best component for scaffold engineering. Along with the apt microenvironment, this material was found to be efficient in differentiating stem cells into specific cell types. Furthermore, the scope of graphene nanomaterials in liver tissue engineering as a promising biomaterial is also discussed. This review critically looks into the unlimited potential of graphene-based nanomaterials in future tissue engineering and regenerative therapy. Dove 2019-07-24 /pmc/articles/PMC6662516/ /pubmed/31413573 http://dx.doi.org/10.2147/IJN.S192779 Text en © 2019 Geetha Bai et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Geetha Bai, Renu
Muthoosamy, Kasturi
Manickam, Sivakumar
Hilal-Alnaqbi, Ali
Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_full Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_fullStr Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_full_unstemmed Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_short Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
title_sort graphene-based 3d scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662516/
https://www.ncbi.nlm.nih.gov/pubmed/31413573
http://dx.doi.org/10.2147/IJN.S192779
work_keys_str_mv AT geethabairenu graphenebased3dscaffoldsintissueengineeringfabricationapplicationsandfuturescopeinlivertissueengineering
AT muthoosamykasturi graphenebased3dscaffoldsintissueengineeringfabricationapplicationsandfuturescopeinlivertissueengineering
AT manickamsivakumar graphenebased3dscaffoldsintissueengineeringfabricationapplicationsandfuturescopeinlivertissueengineering
AT hilalalnaqbiali graphenebased3dscaffoldsintissueengineeringfabricationapplicationsandfuturescopeinlivertissueengineering