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Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering
Tissue engineering embraces the potential of recreating and replacing defective body parts by advancements in the medical field. Being a biocompatible nanomaterial with outstanding physical, chemical, optical, and biological properties, graphene-based materials were successfully employed in creating...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662516/ https://www.ncbi.nlm.nih.gov/pubmed/31413573 http://dx.doi.org/10.2147/IJN.S192779 |
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author | Geetha Bai, Renu Muthoosamy, Kasturi Manickam, Sivakumar Hilal-Alnaqbi, Ali |
author_facet | Geetha Bai, Renu Muthoosamy, Kasturi Manickam, Sivakumar Hilal-Alnaqbi, Ali |
author_sort | Geetha Bai, Renu |
collection | PubMed |
description | Tissue engineering embraces the potential of recreating and replacing defective body parts by advancements in the medical field. Being a biocompatible nanomaterial with outstanding physical, chemical, optical, and biological properties, graphene-based materials were successfully employed in creating the perfect scaffold for a range of organs, starting from the skin through to the brain. Investigations on 2D and 3D tissue culture scaffolds incorporated with graphene or its derivatives have revealed the capability of this carbon material in mimicking in vivo environment. The porous morphology, great surface area, selective permeability of gases, excellent mechanical strength, good thermal and electrical conductivity, good optical properties, and biodegradability enable graphene materials to be the best component for scaffold engineering. Along with the apt microenvironment, this material was found to be efficient in differentiating stem cells into specific cell types. Furthermore, the scope of graphene nanomaterials in liver tissue engineering as a promising biomaterial is also discussed. This review critically looks into the unlimited potential of graphene-based nanomaterials in future tissue engineering and regenerative therapy. |
format | Online Article Text |
id | pubmed-6662516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-66625162019-08-14 Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering Geetha Bai, Renu Muthoosamy, Kasturi Manickam, Sivakumar Hilal-Alnaqbi, Ali Int J Nanomedicine Review Tissue engineering embraces the potential of recreating and replacing defective body parts by advancements in the medical field. Being a biocompatible nanomaterial with outstanding physical, chemical, optical, and biological properties, graphene-based materials were successfully employed in creating the perfect scaffold for a range of organs, starting from the skin through to the brain. Investigations on 2D and 3D tissue culture scaffolds incorporated with graphene or its derivatives have revealed the capability of this carbon material in mimicking in vivo environment. The porous morphology, great surface area, selective permeability of gases, excellent mechanical strength, good thermal and electrical conductivity, good optical properties, and biodegradability enable graphene materials to be the best component for scaffold engineering. Along with the apt microenvironment, this material was found to be efficient in differentiating stem cells into specific cell types. Furthermore, the scope of graphene nanomaterials in liver tissue engineering as a promising biomaterial is also discussed. This review critically looks into the unlimited potential of graphene-based nanomaterials in future tissue engineering and regenerative therapy. Dove 2019-07-24 /pmc/articles/PMC6662516/ /pubmed/31413573 http://dx.doi.org/10.2147/IJN.S192779 Text en © 2019 Geetha Bai et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Geetha Bai, Renu Muthoosamy, Kasturi Manickam, Sivakumar Hilal-Alnaqbi, Ali Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering |
title | Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering |
title_full | Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering |
title_fullStr | Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering |
title_full_unstemmed | Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering |
title_short | Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering |
title_sort | graphene-based 3d scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662516/ https://www.ncbi.nlm.nih.gov/pubmed/31413573 http://dx.doi.org/10.2147/IJN.S192779 |
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