Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug–Drug Interaction and Associated Biomarker Levels in Healthy Volunteers

Understanding transporter‐mediated drug–drug interactions is an integral part of risk assessment in drug development. Recent studies support the use of hexadecanedioate (HDA), tetradecanedioate (TDA), coproporphyrin (CP)‐I, and CP‐III as clinical biomarkers for evaluating organic anion‐transporting...

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Detalles Bibliográficos
Autores principales: Yee, Sook Wah, Giacomini, Marilyn M., Shen, Hong, Humphreys, W. Griffith, Horng, Howard, Brian, William, Lai, Yurong, Kroetz, Deanna L., Giacomini, Kathleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662551/
https://www.ncbi.nlm.nih.gov/pubmed/30982223
http://dx.doi.org/10.1111/cts.12625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662551/
https://www.ncbi.nlm.nih.gov/pubmed/30982223
http://dx.doi.org/10.1111/cts.12625

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