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Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery
Accurate survival estimations in Ewing sarcoma are necessary to develop risk- and response adaptive treatment strategies allowing for early decision-making. We aim to develop an easy-to-use survival estimation tool from diagnosis and surgery. A retrospective study of 1314 Ewing sarcoma patients was...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662666/ https://www.ncbi.nlm.nih.gov/pubmed/31358784 http://dx.doi.org/10.1038/s41598-019-46721-8 |
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author | Bosma, S. E. Lancia, C. Rueten-Budde, A. J. Ranft, A. Gelderblom, H. Fiocco, M. van de Sande, M. A. J. Dijkstra, P. D. S. Dirksen, U. |
author_facet | Bosma, S. E. Lancia, C. Rueten-Budde, A. J. Ranft, A. Gelderblom, H. Fiocco, M. van de Sande, M. A. J. Dijkstra, P. D. S. Dirksen, U. |
author_sort | Bosma, S. E. |
collection | PubMed |
description | Accurate survival estimations in Ewing sarcoma are necessary to develop risk- and response adaptive treatment strategies allowing for early decision-making. We aim to develop an easy-to-use survival estimation tool from diagnosis and surgery. A retrospective study of 1314 Ewing sarcoma patients was performed. Associations between prognostic variables at diagnosis/surgery and overall survival (OS), were investigated using Kaplan-Meier and multivariate Cox models. Predictive accuracy was evaluated by cross-validation and Harrell C-statistics. Median follow-up was 7.9 years (95%CI 7.6–8.3). Independent prognostic factors at diagnosis were age, volume, primary tumor localization and disease extent. 5 risk categories (A-E) were identified with 5-year OS of 88% (86–94), 69% (64–74), 57% (50–64), 51% (42–60) and 28% (22–34) respectively. Harrell C-statistic was 0.70. Independent prognostic factors from surgery were age, volume, disease extent and histological response. In categories A-B, 5y OS increased to 92% (87–97) and 79% (71–87) respectively for 100% necrosis and decreased to 76% (67–85) and 62% (55–69) respectively for <100% necrosis. In categories C-E, 5y OS increased to 65% (55–75), 65% (52–78) and 52% (38–66) respectively for ≥90% necrosis and decreased to 38% (22–54), 11% (0–26) and 7% (0–19) respectively for <90% necrosis. We present an easy-to-use survival estimation tool from diagnosis in Ewing sarcoma based on age, volume, primary tumor localization and disease extent. Histological response is a strong additional prognostic factor for OS. |
format | Online Article Text |
id | pubmed-6662666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66626662019-08-02 Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery Bosma, S. E. Lancia, C. Rueten-Budde, A. J. Ranft, A. Gelderblom, H. Fiocco, M. van de Sande, M. A. J. Dijkstra, P. D. S. Dirksen, U. Sci Rep Article Accurate survival estimations in Ewing sarcoma are necessary to develop risk- and response adaptive treatment strategies allowing for early decision-making. We aim to develop an easy-to-use survival estimation tool from diagnosis and surgery. A retrospective study of 1314 Ewing sarcoma patients was performed. Associations between prognostic variables at diagnosis/surgery and overall survival (OS), were investigated using Kaplan-Meier and multivariate Cox models. Predictive accuracy was evaluated by cross-validation and Harrell C-statistics. Median follow-up was 7.9 years (95%CI 7.6–8.3). Independent prognostic factors at diagnosis were age, volume, primary tumor localization and disease extent. 5 risk categories (A-E) were identified with 5-year OS of 88% (86–94), 69% (64–74), 57% (50–64), 51% (42–60) and 28% (22–34) respectively. Harrell C-statistic was 0.70. Independent prognostic factors from surgery were age, volume, disease extent and histological response. In categories A-B, 5y OS increased to 92% (87–97) and 79% (71–87) respectively for 100% necrosis and decreased to 76% (67–85) and 62% (55–69) respectively for <100% necrosis. In categories C-E, 5y OS increased to 65% (55–75), 65% (52–78) and 52% (38–66) respectively for ≥90% necrosis and decreased to 38% (22–54), 11% (0–26) and 7% (0–19) respectively for <90% necrosis. We present an easy-to-use survival estimation tool from diagnosis in Ewing sarcoma based on age, volume, primary tumor localization and disease extent. Histological response is a strong additional prognostic factor for OS. Nature Publishing Group UK 2019-07-29 /pmc/articles/PMC6662666/ /pubmed/31358784 http://dx.doi.org/10.1038/s41598-019-46721-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bosma, S. E. Lancia, C. Rueten-Budde, A. J. Ranft, A. Gelderblom, H. Fiocco, M. van de Sande, M. A. J. Dijkstra, P. D. S. Dirksen, U. Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery |
title | Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery |
title_full | Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery |
title_fullStr | Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery |
title_full_unstemmed | Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery |
title_short | Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery |
title_sort | easy-to-use clinical tool for survival estimation in ewing sarcoma at diagnosis and after surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662666/ https://www.ncbi.nlm.nih.gov/pubmed/31358784 http://dx.doi.org/10.1038/s41598-019-46721-8 |
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