Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability

The initiation of centrosome duplication is regulated by the Plk4/STIL/hsSAS-6 axis; however, the involvement of other centrosomal proteins in this process remains unclear. In this study, we demonstrate that Cep131 physically interacts with Plk4 following phosphorylation of residues S21 and T205. Lo...

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Detalles Bibliográficos
Autores principales: Kim, Dong Hyun, Ahn, Jong Seog, Han, Ho Jin, Kim, Hye-Min, Hwang, Joonsung, Lee, Kyung Ho, Cha-Molstad, Hyunjoo, Ryoo, In-Ja, Jang, Jae-Hyuk, Ko, Sung-Kyun, Yang, Jin Ok, Lee, Hee Gu, Lee, Sangku, Song, Eun Joo, Kim, Jin Young, Huh, Yang Hoon, Kwon, Yong Tae, Soung, Nak-Kyun, Kim, Bo Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662699/
https://www.ncbi.nlm.nih.gov/pubmed/31358734
http://dx.doi.org/10.1038/s41419-019-1778-8

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