CRISPR-CasX is an RNA-dominated enzyme active for human genome editing

The RNA-guided CRISPR-associated (Cas) proteins Cas9 and Cas12a provide adaptive immunity against bacteriophage and function as powerful tools for genome editing in wide-ranging cell types. Here we present a third and fundamentally distinct RNA-guided platform, CRISPR-CasX, which uses a unique struc...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jun-Jie, Orlova, Natalia, Oakes, Benjamin L., Ma, Enbo, Spinner, Hannah B., Baney, Katherine L.M., Chuck, Jonathan, Tan, Dan, Knott, Gavin J., Harrington, Lucas B., Al-Shayeb, Basem, Wagner, Alexander, Brötzmann, Julian, Staahl, Brett T., Talyor, Kian L., Desmarais, John, Nogales, Eva, Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662743/
https://www.ncbi.nlm.nih.gov/pubmed/30718774
http://dx.doi.org/10.1038/s41586-019-0908-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662743/
https://www.ncbi.nlm.nih.gov/pubmed/30718774
http://dx.doi.org/10.1038/s41586-019-0908-x

Ejemplares similares