Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart

Cardiac fibrosis is an underlying cause of diastolic dysfunction, contributing to heart failure. Substance P (SP) activation of the neurokinin-1 receptor (NK-1R) contributes to cardiac fibrosis in hypertension. However, based on in vitro experiments, this does not appear to be via direct activation...

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Detalles Bibliográficos
Autores principales: Widiapradja, Alexander, Manteufel, Edward J., Dehlin, Heather M., Pena, James, Goldspink, Paul H., Sharma, Amit, Kolb, Lauren L., Imig, John D., Janicki, Joseph S., Lu, Bao, Levick, Scott P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662794/
https://www.ncbi.nlm.nih.gov/pubmed/31358823
http://dx.doi.org/10.1038/s41598-019-47369-0

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