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Catalytically Competent Non-transforming H-RAS(G12P) Mutant Provides Insight into Molecular Switch Function and GAP-independent GTPase Activity of RAS
RAS mutants have been extensively studied as they are associated with development of cancer; however, H-RAS(G12P) mutant has remained untouched since it does not lead to transformation in the cell. To the best of our knowledge, this is the first study where structural/dynamical properties of H-RAS(G...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662853/ https://www.ncbi.nlm.nih.gov/pubmed/31358828 http://dx.doi.org/10.1038/s41598-019-47481-1 |