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Simulation of action potential propagation based on the ghost structure method

In this paper, a ghost structure (GS) method is proposed to simulate the monodomain model in irregular computational domains using finite difference without regenerating body-fitted grids. In order to verify the validity of the GS method, it is first used to solve the Fitzhugh-Nagumo monodomain mode...

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Autores principales: Wang, Yongheng, Cai, Li, Luo, Xiaoyu, Ying, Wenjun, Gao, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662858/
https://www.ncbi.nlm.nih.gov/pubmed/31358816
http://dx.doi.org/10.1038/s41598-019-47321-2
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author Wang, Yongheng
Cai, Li
Luo, Xiaoyu
Ying, Wenjun
Gao, Hao
author_facet Wang, Yongheng
Cai, Li
Luo, Xiaoyu
Ying, Wenjun
Gao, Hao
author_sort Wang, Yongheng
collection PubMed
description In this paper, a ghost structure (GS) method is proposed to simulate the monodomain model in irregular computational domains using finite difference without regenerating body-fitted grids. In order to verify the validity of the GS method, it is first used to solve the Fitzhugh-Nagumo monodomain model in rectangular and circular regions at different states (the stationary and moving states). Then, the GS method is used to simulate the propagation of the action potential (AP) in transverse and longitudinal sections of a healthy human heart, and with left bundle branch block (LBBB). Finally, we analyze the AP and calcium concentration under healthy and LBBB conditions. Our numerical results show that the GS method can accurately simulate AP propagation with different computational domains either stationary or moving, and we also find that LBBB will cause the left ventricle to contract later than the right ventricle, which in turn affects synchronized contraction of the two ventricles.
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spelling pubmed-66628582019-08-02 Simulation of action potential propagation based on the ghost structure method Wang, Yongheng Cai, Li Luo, Xiaoyu Ying, Wenjun Gao, Hao Sci Rep Article In this paper, a ghost structure (GS) method is proposed to simulate the monodomain model in irregular computational domains using finite difference without regenerating body-fitted grids. In order to verify the validity of the GS method, it is first used to solve the Fitzhugh-Nagumo monodomain model in rectangular and circular regions at different states (the stationary and moving states). Then, the GS method is used to simulate the propagation of the action potential (AP) in transverse and longitudinal sections of a healthy human heart, and with left bundle branch block (LBBB). Finally, we analyze the AP and calcium concentration under healthy and LBBB conditions. Our numerical results show that the GS method can accurately simulate AP propagation with different computational domains either stationary or moving, and we also find that LBBB will cause the left ventricle to contract later than the right ventricle, which in turn affects synchronized contraction of the two ventricles. Nature Publishing Group UK 2019-07-29 /pmc/articles/PMC6662858/ /pubmed/31358816 http://dx.doi.org/10.1038/s41598-019-47321-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wang, Yongheng
Cai, Li
Luo, Xiaoyu
Ying, Wenjun
Gao, Hao
Simulation of action potential propagation based on the ghost structure method
title Simulation of action potential propagation based on the ghost structure method
title_full Simulation of action potential propagation based on the ghost structure method
title_fullStr Simulation of action potential propagation based on the ghost structure method
title_full_unstemmed Simulation of action potential propagation based on the ghost structure method
title_short Simulation of action potential propagation based on the ghost structure method
title_sort simulation of action potential propagation based on the ghost structure method
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662858/
https://www.ncbi.nlm.nih.gov/pubmed/31358816
http://dx.doi.org/10.1038/s41598-019-47321-2
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